Detailed information of TA system TA218117

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 349973..350239
• Replicon: chromosome
• Accession: NZ_CP084107
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: LB316_RS01670
• Protein ID: WP_000253687.1
• Coordinates: 349973..350080 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	350070..350239 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB316_RS01650	345134..348814	+	3681	WP_229375527.1	phage tail spike protein	-
LB316_RS01655	348801..348953	+	153	WP_229374177.1	hypothetical protein	-
LB316_RS01660	349000..349287	+	288	WP_229374179.1	hypothetical protein	-
LB316_RS01665	349382..349750	+	369	WP_229374782.1	hypothetical protein	-
LB316_RS01670	349973..350080	+	108	WP_000253687.1	putative holin-like toxin	Toxin
-	350070..350239	-	170	-	-	Antitoxin
LB316_RS01680	350289..350543	+	255	WP_229374181.1	phage holin	-
LB316_RS01685	350555..351310	+	756	WP_229375529.1	CHAP domain-containing protein	-
LB316_RS01690	352086..352418	+	333	Protein_336	SH3 domain-containing protein	-
LB316_RS01695	352807..353745	+	939	WP_229374185.1	leukocidin/hemolysin toxin family protein	-
LB316_RS01700	353741..354724	+	984	WP_229374783.1	Panton-Valentine bi-component leukocidin subunit F	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh / lukS-PV / lukF-PV	306845..354724	47879

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T218117 WP_000253687.1 NZ_CP084107:349973-350080 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T218117 NZ_CP115551:c4313100-4312756 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGCAAAACGTTTTATCACTGCCTTCACCGGCAGCGACCCCGTCACGCTTGTCGCCCGTCGAAGCCTGGCGAAAACTGCT
GTCGTATTTACTGCAACGCCACTACGGCCTGGAACTCAACGACACGCCATTCTGCGACGATAGTGTTATTCAGGAACATA
TCAACGCAGGCGTTACGCTTGCCGATGCCGTGAACTTTCTGGTGGAAAAGTACGAACTTGTTCGTATCGATCGCAAGGGA
TTTAGCTGGCAGGAACCATCACCTTATCTCCGGGCTGTCGATATTCTGCGGGCGCGACAGGTAACAGGTCTGTTGCGACG
TCGCCGTAATCTCGCGGCACACTGA

Antitoxin

Nucleotide

• Length: 170 bp

>AT218117 NZ_CP084107:c350239-350070 [Staphylococcus aureus]
ATTTGATATTTATTTCATAGTGTGTTAATTTATAAATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTGTAGTTAAATGAATTTATATAATCATCTAACCATCGTACTCGTCAAAGTTAGCGATGGT
TATTTTTTAT

Structures

Antitoxin