Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 114217..114944 | Replicon | plasmid pC11-215kb |
| Accession | NZ_CP084104 | ||
| Organism | Klebsiella pneumoniae strain C11 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | K8M04_RS25730 | Protein ID | WP_011251285.1 |
| Coordinates | 114633..114944 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K8M04_RS25725 | Protein ID | WP_011251286.1 |
| Coordinates | 114217..114636 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8M04_RS25700 (K8M04_25630) | 109809..111176 | + | 1368 | WP_017900870.1 | formimidoylglutamate deiminase | - |
| K8M04_RS25705 (K8M04_25635) | 111701..112236 | + | 536 | Protein_117 | transposase | - |
| K8M04_RS25710 (K8M04_25640) | 112350..112616 | - | 267 | WP_017900868.1 | hypothetical protein | - |
| K8M04_RS25715 (K8M04_25645) | 112720..113688 | + | 969 | WP_074168518.1 | IS5-like element IS903B family transposase | - |
| K8M04_RS25720 (K8M04_25650) | 113734..114147 | - | 414 | WP_017901337.1 | hypothetical protein | - |
| K8M04_RS25725 (K8M04_25655) | 114217..114636 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| K8M04_RS25730 (K8M04_25660) | 114633..114944 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| K8M04_RS25735 (K8M04_25665) | 115149..115586 | - | 438 | Protein_123 | DDE-type integrase/transposase/recombinase | - |
| K8M04_RS25740 (K8M04_25670) | 115700..116077 | + | 378 | WP_004118218.1 | transposase | - |
| K8M04_RS25745 (K8M04_25675) | 116074..116421 | + | 348 | WP_032430752.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| K8M04_RS25750 (K8M04_25680) | 116470..118008 | + | 1539 | WP_017901237.1 | IS66 family transposase | - |
| K8M04_RS25755 (K8M04_25685) | 118048..118227 | + | 180 | Protein_127 | IS5/IS1182 family transposase | - |
| K8M04_RS25760 (K8M04_25690) | 118290..119212 | + | 923 | Protein_128 | IS5 family transposase | - |
| K8M04_RS25765 (K8M04_25695) | 119268..119528 | + | 261 | Protein_129 | integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..215108 | 215108 | |
| - | inside | IScluster/Tn | - | - | 112720..125075 | 12355 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T218115 WP_011251285.1 NZ_CP084104:c114944-114633 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T218115 NZ_CP115551:c4271335-4271048 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT218115 WP_011251286.1 NZ_CP084104:c114636-114217 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT218115 NZ_CP115551:c4271061-4270759 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|