Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 323287..323873 Replicon chromosome
Accession NZ_CP084103
Organism Klebsiella pneumoniae strain C11

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K8M04_RS01495 Protein ID WP_002920800.1
Coordinates 323505..323873 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K8M04_RS01490 Protein ID WP_004174006.1
Coordinates 323287..323508 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M04_RS01470 (K8M04_01470) 319444..320370 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K8M04_RS01475 (K8M04_01475) 320367..321644 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K8M04_RS01480 (K8M04_01480) 321641..322408 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K8M04_RS01485 (K8M04_01485) 322410..323123 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K8M04_RS01490 (K8M04_01490) 323287..323508 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8M04_RS01495 (K8M04_01495) 323505..323873 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K8M04_RS01500 (K8M04_01500) 324146..325462 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K8M04_RS01505 (K8M04_01505) 325569..326456 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K8M04_RS01510 (K8M04_01510) 326453..327298 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K8M04_RS01515 (K8M04_01515) 327300..328370 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 318273..329107 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T218097 WP_002920800.1 NZ_CP084103:323505-323873 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T218097 NZ_CP115463:c4146477-4145998 [Caulobacter sp. NIBR1757]
GTGAGCCGGCGGCTCTGGCGAATCGCGGCGGATACGCCGGACTACGAGGCGGACGACCTGTCCGGCGCGGGGGCCAGGAT
CACTGGCGGGCGGTGGAACGCGCCTGGATCCGCCGTTGTCTACACGTCGGCATCCATCGCCCTGGCCTGTCTCGAAACGG
TCGTTCACTTCAACGCGGGCGGCCTTCCGTTCAACCGCTATCTGGTCGCCATCGATATTCCGGATTCCGTCTGGGCCGCC
GCGCAACGGGAAACGCCTGCCAGCCTGCCGGTCGGGTGGGATGCCGAACCCGCCGGACGGGTCAGCATTGGTCTGGGAAC
CGACTGGATCGCCTCGGGCGCCTCGGCCTTGCTGATCGTTCCCTCGGTCCTCGTGCCTGAGGAGATCAACATCCTGATCA
ATCCGACCCACCCGGACGCCGGGGGGATCACGGCCGGCAAGATCCGAAAATGGACCTATGATCCGCGACTGTCGCGATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT218097 WP_004174006.1 NZ_CP084103:323287-323508 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT218097 NZ_CP115463:c4146899-4146474 [Caulobacter sp. NIBR1757]
ATGTCCTATATCGACATCTATCGGGCCGAGCCGGTCGTTCGCATCGGGATGATCAAGGCCGGCGTCCCCGCCGCCCAGGC
CAAGCGCATCTTTCATGATCTGGCGATCAGTCAGGGCGCCGGGCTCTCGGCCCTCAAGCTGTCGGCGGCGACCGTCAATC
GCAAGGCGTCGCAGGACGCGACCCTGTCGGCCGACGAGAGTGAACGCGTCATCGGCGTCGCCAAGCTCGTCGGCCAACTC
CAGGCCATGGTCGAGGAGTCCGGCGATCCGCAAGGGTTCGATGCGCCGGCCTGGCTGTCGCGCTGGCTTCGGGAGCCGCT
GCCGGCCCTCGGGGGTCAGGCGCCCATGACCTTGCTCGATACGATGGAGGGCCAGTCCCTGGTCTCCCGCACCTTGTCCC
AAATTCAGAGCGGCGCTTACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References