Detailed information of TA system TA218043

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2670166..2670387
• Replicon: chromosome
• Accession: NZ_CP084055
• Organism: Escherichia coli strain X14-3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: LCR13_RS13150
• Protein ID: WP_000141634.1
• Coordinates: 2670166..2670273 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2670322..2670387 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCR13_RS13125 (2665419)	2665419..2666171	-	753	WP_000279528.1	cellulose biosynthesis protein BcsQ	-
LCR13_RS13130 (2666183)	2666183..2666371	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
LCR13_RS13135 (2666644)	2666644..2668215	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LCR13_RS13140 (2668212)	2668212..2668403	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LCR13_RS13145 (2668400)	2668400..2670079	+	1680	WP_073464209.1	cellulose biosynthesis protein BcsG	-
LCR13_RS13150 (2670166)	2670166..2670273	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
- (2670322)	2670322..2670387	+	66	NuclAT_13	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_13	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_13	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_13	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_26	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_26	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_26	-	Antitoxin
- (2670322)	2670322..2670387	+	66	NuclAT_26	-	Antitoxin
LCR13_RS13155 (2670749)	2670749..2672020	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
LCR13_RS13160 (2672050)	2672050..2673054	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LCR13_RS13165 (2673051)	2673051..2674034	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LCR13_RS13170 (2674045)	2674045..2674947	-	903	WP_096006704.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T218043 WP_000141634.1 NZ_CP084055:c2670273-2670166 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T218043 NZ_CP115447:c1962077-1961748 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT218043 NZ_CP084055:2670322-2670387 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• PDB: 5LBJ

Antitoxin