Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2160851..2161544 Replicon chromosome
Accession NZ_CP084055
Organism Escherichia coli strain X14-3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LCR13_RS10640 Protein ID WP_000415584.1
Coordinates 2161248..2161544 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LCR13_RS10635 Protein ID WP_000650107.1
Coordinates 2160851..2161246 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCR13_RS10625 (2156715) 2156715..2158973 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
LCR13_RS10630 (2159111) 2159111..2160718 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LCR13_RS10635 (2160851) 2160851..2161246 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LCR13_RS10640 (2161248) 2161248..2161544 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LCR13_RS10645 (2161749) 2161749..2162231 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LCR13_RS10650 (2162284) 2162284..2162676 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LCR13_RS10655 (2162828) 2162828..2163487 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LCR13_RS10660 (2163484) 2163484..2164833 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LCR13_RS10670 (2165855) 2165855..2166436 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2164928..2165431 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T218041 WP_000415584.1 NZ_CP084055:c2161544-2161248 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T218041 NZ_CP115447:c1722057-1721668 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCGCGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT218041 WP_000650107.1 NZ_CP084055:c2161246-2160851 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT218041 NZ_CP115447:c1722281-1722054 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References