Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 572196..572889 Replicon chromosome
Accession NZ_CP084026
Organism Escherichia coli strain 035053C1pKPC2_Vir_090515B1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LC440_RS02865 Protein ID WP_000415584.1
Coordinates 572196..572492 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LC440_RS02870 Protein ID WP_000650107.1
Coordinates 572494..572889 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC440_RS02830 (567284) 567284..567598 - 315 WP_000958598.1 putative quinol monooxygenase -
LC440_RS02835 (567629) 567629..568210 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LC440_RS02840 (568529) 568529..568861 + 333 WP_000917684.1 DUF2645 family protein -
LC440_RS02845 (568907) 568907..570256 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LC440_RS02850 (570253) 570253..570912 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LC440_RS02855 (571064) 571064..571456 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LC440_RS02860 (571509) 571509..571991 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LC440_RS02865 (572196) 572196..572492 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LC440_RS02870 (572494) 572494..572889 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LC440_RS02875 (573022) 573022..574629 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LC440_RS02880 (574767) 574767..577025 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217954 WP_000415584.1 NZ_CP084026:572196-572492 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217954 NZ_CP114896:c676629-676522 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217954 WP_000650107.1 NZ_CP084026:572494-572889 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217954 NZ_CP114896:676677-676743 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References