Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4265839..4266341 Replicon chromosome
Accession NZ_CP084023
Organism Pectobacterium aroidearum strain LJ2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7W2E5L4
Locus tag LCF43_RS19240 Protein ID WP_039282578.1
Coordinates 4266087..4266341 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag LCF43_RS19235 Protein ID WP_039324900.1
Coordinates 4265839..4266090 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF43_RS19220 4262239..4263198 + 960 WP_012773138.1 ABC transporter permease -
LCF43_RS19225 4263191..4264057 + 867 WP_010285293.1 ABC transporter permease -
LCF43_RS19230 4264054..4265763 + 1710 WP_225181558.1 ABC transporter ATP-binding protein -
LCF43_RS19235 4265839..4266090 + 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LCF43_RS19240 4266087..4266341 + 255 WP_039282578.1 Txe/YoeB family addiction module toxin Toxin
LCF43_RS19245 4266401..4267255 - 855 WP_225181559.1 helix-turn-helix domain-containing protein -
LCF43_RS19250 4267280..4268119 - 840 WP_180778897.1 HTH-type transcriptional activator RhaS -
LCF43_RS19255 4268455..4269945 + 1491 WP_225181560.1 rhamnulokinase -
LCF43_RS19260 4269942..4271204 + 1263 WP_225181561.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.79 Da        Isoelectric Point: 8.0353

>T217948 WP_039282578.1 NZ_CP084023:4266087-4266341 [Pectobacterium aroidearum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T217948 NZ_CP114895:c3553054-3552719 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT217948 WP_039324900.1 NZ_CP084023:4265839-4266090 [Pectobacterium aroidearum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT217948 NZ_CP114895:c3553302-3553054 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E5L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References