Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25384..26056 Replicon chromosome
Accession NZ_CP084023
Organism Pectobacterium aroidearum strain LJ2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LCF43_RS00115 Protein ID WP_180779426.1
Coordinates 25670..26056 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LCF43_RS00110 Protein ID WP_180779427.1
Coordinates 25384..25683 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF43_RS00090 20619..21626 + 1008 WP_225181731.1 nucleoside hydrolase -
LCF43_RS00095 21626..22603 + 978 WP_012772765.1 ABC transporter permease -
LCF43_RS00100 22600..23508 + 909 WP_012772766.1 ABC transporter permease -
LCF43_RS00105 23548..25347 + 1800 WP_225181732.1 ABC transporter ATP-binding protein -
LCF43_RS00110 25384..25683 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
LCF43_RS00115 25670..26056 - 387 WP_180779426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCF43_RS00120 26272..26769 + 498 WP_225181733.1 GNAT family N-acetyltransferase -
LCF43_RS00125 26969..27226 - 258 WP_225181734.1 DUF1471 domain-containing protein -
LCF43_RS00130 27399..28199 - 801 WP_205947326.1 aliphatic sulfonates ABC transporter ATP-binding protein -
LCF43_RS00135 28196..28990 - 795 WP_180779424.1 aliphatic sulfonate ABC transporter permease SsuC -
LCF43_RS00140 29001..30143 - 1143 WP_180779423.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14834.84 Da        Isoelectric Point: 4.7331

>T217940 WP_180779426.1 NZ_CP084023:c26056-25670 [Pectobacterium aroidearum]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 387 bp

>T217940 NZ_CP114895:c2232486-2231164 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT217940 WP_180779427.1 NZ_CP084023:c25683-25384 [Pectobacterium aroidearum]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT217940 NZ_CP114895:c2232752-2232486 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References