Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 78665..79329 Replicon plasmid unnamed1
Accession NZ_CP084013
Organism Bifidobacterium longum strain NBRC 114370

Toxin (Protein)


Gene name HigB2 Uniprot ID A0A395XW84
Locus tag LCQ81_RS10935 Protein ID WP_032737050.1
Coordinates 78665..79024 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LCQ81_RS10940 Protein ID WP_007056001.1
Coordinates 79021..79329 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCQ81_RS10900 (LCQ81_10900) 73959..74507 - 549 WP_225090428.1 CHAP domain-containing protein -
LCQ81_RS10905 (LCQ81_10905) 74708..75019 - 312 WP_007055002.1 hypothetical protein -
LCQ81_RS10910 (LCQ81_10910) 75242..75835 + 594 WP_225090429.1 IS607 family transposase -
LCQ81_RS10915 (LCQ81_10915) 75822..77144 + 1323 WP_225090430.1 IS607 family element RNA-guided endonuclease TnpB -
LCQ81_RS10920 (LCQ81_10920) 77163..77441 - 279 WP_225090431.1 hypothetical protein -
LCQ81_RS10925 (LCQ81_10925) 77438..77932 - 495 WP_225090432.1 hypothetical protein -
LCQ81_RS10930 (LCQ81_10930) 78012..78608 - 597 WP_101026240.1 hypothetical protein -
LCQ81_RS10935 (LCQ81_10935) 78665..79024 + 360 WP_032737050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCQ81_RS10940 (LCQ81_10940) 79021..79329 + 309 WP_007056001.1 helix-turn-helix domain-containing protein Antitoxin
LCQ81_RS10945 (LCQ81_10945) 79344..79631 - 288 WP_007055993.1 hypothetical protein -
LCQ81_RS10950 (LCQ81_10950) 80146..81342 + 1197 WP_225090433.1 RNA-guided endonuclease TnpB family protein -
LCQ81_RS10955 (LCQ81_10955) 81508..81801 - 294 WP_007058386.1 hypothetical protein -
LCQ81_RS10960 (LCQ81_10960) 82222..82548 + 327 WP_124226571.1 hypothetical protein -
LCQ81_RS10965 (LCQ81_10965) 82564..83040 + 477 WP_225090434.1 hypothetical protein -
LCQ81_RS10970 (LCQ81_10970) 83108..83953 + 846 WP_225090435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..169194 169194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-84)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13985.16 Da        Isoelectric Point: 10.0940

>T217936 WP_032737050.1 NZ_CP084013:78665-79024 [Bifidobacterium longum]
MWQIEMEPIKDWLDGLDKQTAYQVYAALDLLRERGPNLKRPLVGKIEGSIIGSMKELRPGSTGRSEVRILFVFDPERKAV
LLVGGDKQNKWNKWYKTAIREAERRYIRWLEEQHGKDTK

Download         Length: 360 bp

>T217936 NZ_CP114895:c1861935-1861828 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11911.52 Da        Isoelectric Point: 5.2707

>AT217936 WP_007056001.1 NZ_CP084013:79021-79329 [Bifidobacterium longum]
MSYTLEDFKADHDLDQKTIDERKEQLLEEMRLYELKEARKQQDVTQKQLAERMGVSQKRVSSLESGDVDKTEIRTLRRYL
DAIGGRLQVNAIMPDGRTLQLV

Download         Length: 309 bp

>AT217936 NZ_CP114895:1861982-1862048 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A395XW84

Antitoxin

Source ID Structure

References