Detailed information of TA system TA217924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4463287..4463889
• Replicon: chromosome
• Accession: NZ_CP084001
• Organism: Salmonella sp. A7

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: LCS67_RS21600
• Protein ID: WP_001159631.1
• Coordinates: 4463578..4463889 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LCS67_RS21595
• Protein ID: WP_000362050.1
• Coordinates: 4463287..4463577 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCS67_RS21580 (4460780)	4460780..4461682	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
LCS67_RS21585 (4461679)	4461679..4462314	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LCS67_RS21590 (4462311)	4462311..4463240	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LCS67_RS21595 (4463287)	4463287..4463577	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LCS67_RS21600 (4463578)	4463578..4463889	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LCS67_RS21605 (4464107)	4464107..4465036	+	930	WP_001127698.1	alpha/beta hydrolase	-
LCS67_RS21610 (4465122)	4465122..4465433	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LCS67_RS21615 (4465430)	4465430..4465876	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LCS67_RS21620 (4465891)	4465891..4466832	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LCS67_RS21625 (4466877)	4466877..4467314	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
LCS67_RS21630 (4467311)	4467311..4468183	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LCS67_RS21635 (4468177)	4468177..4468776	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T217924 WP_001159631.1 NZ_CP084001:c4463889-4463578 [Salmonella sp. A7]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T217924 NZ_CP114894:c4175768-4175490 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT217924 WP_000362050.1 NZ_CP084001:c4463577-4463287 [Salmonella sp. A7]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT217924 NZ_CP114894:c4176031-4175771 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3