Detailed information of TA system TA217875

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 183529..183751
• Replicon: chromosome
• Accession: NZ_CP083990
• Organism: Escherichia coli strain EC2648-Vir2

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: LCH23_RS00880
• Protein ID: WP_000141634.1
• Coordinates: 183644..183751 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	183529..183595 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCH23_RS00860	178970..179872	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
LCH23_RS00865	179883..180866	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LCH23_RS00870	180863..181867	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LCH23_RS00875	181897..183168	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	183529..183595	-	67	-	-	Antitoxin
LCH23_RS00880	183644..183751	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
LCH23_RS00885	183838..185517	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
LCH23_RS00890	185514..185705	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LCH23_RS00895	185702..187273	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LCH23_RS00900	187546..187734	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
LCH23_RS00905	187770..188498	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T217875 WP_000141634.1 NZ_CP083990:183644-183751 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T217875 NZ_CP114892:4048101-4048499 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT217875 NZ_CP083990:c183595-183529 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin