Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3096049..3096662 Replicon chromosome
Accession NZ_CP083952
Organism Mesorhizobium sp. B2-1-8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FJ970_RS15175 Protein ID WP_140758979.1
Coordinates 3096366..3096662 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FJ970_RS15170 Protein ID WP_140758980.1
Coordinates 3096049..3096357 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ970_RS15155 (FJ970_15155) 3092138..3093316 - 1179 WP_140758983.1 lytic murein transglycosylase -
FJ970_RS15160 (FJ970_15160) 3093554..3094354 - 801 WP_140758982.1 GH25 family lysozyme -
FJ970_RS15165 (FJ970_15165) 3094642..3096021 + 1380 WP_140758981.1 serine hydrolase -
FJ970_RS15170 (FJ970_15170) 3096049..3096357 - 309 WP_140758980.1 HigA family addiction module antitoxin Antitoxin
FJ970_RS15175 (FJ970_15175) 3096366..3096662 - 297 WP_140758979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJ970_RS15180 (FJ970_15180) 3096796..3097461 - 666 WP_140758978.1 class I SAM-dependent methyltransferase -
FJ970_RS15185 (FJ970_15185) 3097458..3098705 - 1248 WP_227792138.1 DUF3419 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11548.01 Da        Isoelectric Point: 6.8802

>T217853 WP_140758979.1 NZ_CP083952:c3096662-3096366 [Mesorhizobium sp. B2-1-8]
VIVGFRDGWLRAFFVEDIHSRNIPSDLESRLFRKLQMIDDAMTDLDLRVPPSNHFEKLRGNLDGFHSIRVNSQWRLIFRW
DGGRGEASGIYLDDHSYR

Download         Length: 297 bp

>T217853 NZ_CP114892:c439634-439527 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11352.07 Da        Isoelectric Point: 9.4051

>AT217853 WP_140758980.1 NZ_CP083952:c3096357-3096049 [Mesorhizobium sp. B2-1-8]
MLMTTRKPATVGEILTEEFMQPLGLTQAALAEAMGVQRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRSDLW
SVMNSPDERARVDRAKPLATAA

Download         Length: 309 bp

>AT217853 NZ_CP114892:439681-439747 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References