Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2320958..2321553 Replicon chromosome
Accession NZ_CP083952
Organism Mesorhizobium sp. B2-1-8

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FJ970_RS11335 Protein ID WP_140759611.1
Coordinates 2321272..2321553 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FJ970_RS11330 Protein ID WP_127278412.1
Coordinates 2320958..2321257 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ970_RS11295 (FJ970_11295) 2316156..2316368 - 213 WP_006202520.1 cold-shock protein -
FJ970_RS11300 (FJ970_11300) 2316952..2317356 + 405 WP_140759379.1 Kazal-type serine protease inhibitor -
FJ970_RS11305 (FJ970_11305) 2317373..2317701 - 329 Protein_2236 NADPH-dependent oxidoreductase -
FJ970_RS11310 (FJ970_11310) 2317895..2319529 + 1635 WP_140759381.1 tetratricopeptide repeat-containing sulfotransferase family protein -
FJ970_RS11315 (FJ970_11315) 2319632..2319985 - 354 WP_140759383.1 DUF1428 family protein -
FJ970_RS11320 (FJ970_11320) 2320085..2320501 - 417 WP_140759385.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
FJ970_RS11325 (FJ970_11325) 2320645..2320827 - 183 WP_023770253.1 hypothetical protein -
FJ970_RS11330 (FJ970_11330) 2320958..2321257 - 300 WP_127278412.1 HigA family addiction module antitoxin Antitoxin
FJ970_RS11335 (FJ970_11335) 2321272..2321553 - 282 WP_140759611.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJ970_RS11340 (FJ970_11340) 2321688..2323214 - 1527 WP_140759387.1 ABC-F family ATP-binding cassette domain-containing protein -
FJ970_RS11345 (FJ970_11345) 2323465..2324370 - 906 WP_140759389.1 DMT family transporter -
FJ970_RS11350 (FJ970_11350) 2324698..2325036 + 339 WP_224595775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10587.96 Da        Isoelectric Point: 8.0341

>T217850 WP_140759611.1 NZ_CP083952:c2321553-2321272 [Mesorhizobium sp. B2-1-8]
MIRSFKDKTSEAVSNGKAPKGFPSDLVRPAQWKLYMIDNAAELSDLKTPPGNRLEPLKGNRAGQHSIRINDQFRICFRWV
DGQAEDVEITDYH

Download         Length: 282 bp

>T217850 NZ_CP114891:c3582947-3582774 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11218.05 Da        Isoelectric Point: 7.2024

>AT217850 WP_127278412.1 NZ_CP083952:c2321257-2320958 [Mesorhizobium sp. B2-1-8]
MLDINPPIHPGEILREEYLIPLGLKPYTLAKKLHVPRTRIERLASETTPVTPDTALRLAKFFGTTPQFWMNMQASYDLAV
EGKAKRADLETIERLETAA

Download         Length: 300 bp

>AT217850 NZ_CP114891:c3583271-3582975 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References