Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 198005..198540 | Replicon | plasmid pV1225-1 |
Accession | NZ_CP083913 | ||
Organism | Enterococcus faecium isolate V1225 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | LCG89_RS14395 | Protein ID | WP_002314366.1 |
Coordinates | 198005..198277 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | LCG89_RS14400 | Protein ID | WP_002297422.1 |
Coordinates | 198277..198540 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LCG89_RS14360 (LCG89_14360) | 193992..194516 | + | 525 | Protein_215 | transposase | - |
LCG89_RS14365 (LCG89_14365) | 194774..195244 | - | 471 | Protein_216 | sigma 54-interacting transcriptional regulator | - |
LCG89_RS14370 (LCG89_14370) | 195285..195933 | + | 649 | Protein_217 | IS6 family transposase | - |
LCG89_RS14375 (LCG89_14375) | 195992..196180 | - | 189 | Protein_218 | hypothetical protein | - |
LCG89_RS14380 (LCG89_14380) | 196181..197038 | - | 858 | WP_002292680.1 | ParA family protein | - |
LCG89_RS14385 (LCG89_14385) | 197323..197609 | - | 287 | Protein_220 | type II toxin-antitoxin system RelE/ParE family toxin | - |
LCG89_RS14390 (LCG89_14390) | 197599..197928 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
LCG89_RS14395 (LCG89_14395) | 198005..198277 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
LCG89_RS14400 (LCG89_14400) | 198277..198540 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LCG89_RS14405 (LCG89_14405) | 198774..199682 | + | 909 | Protein_224 | IS982 family transposase | - |
LCG89_RS14410 (LCG89_14410) | 199685..200860 | - | 1176 | WP_002336205.1 | MFS transporter | - |
LCG89_RS14415 (LCG89_14415) | 200863..203112 | - | 2250 | WP_002314387.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..213284 | 213284 | |
- | inside | IScluster/Tn | - | - | 189030..211032 | 22002 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T217796 WP_002314366.1 NZ_CP083913:c198277-198005 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T217796 NZ_CP114853:794230-794640 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT217796 WP_002297422.1 NZ_CP083913:c198540-198277 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT217796 NZ_CP114853:793983-794249 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |