Detailed information of TA system TA021779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3593262..3593840
• Replicon: chromosome
• Accession: NC_008576
• Organism: Magnetococcus marinus MC-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0LBP3
• Locus tag: MMC1_RS14810
• Protein ID: WP_011714454.1
• Coordinates: 3593262..3593540 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMC1_RS14815
• Protein ID: WP_011714455.1
• Coordinates: 3593553..3593840 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMC1_RS14775	3588408..3588779	-	372	WP_011714448.1	hypothetical protein	-
MMC1_RS14780	3588782..3589699	-	918	WP_011714449.1	hypothetical protein	-
MMC1_RS14785	3589711..3589968	-	258	WP_011712995.1	hypothetical protein	-
MMC1_RS14790	3589971..3590288	-	318	WP_011714450.1	hypothetical protein	-
MMC1_RS14795	3590291..3591304	-	1014	WP_011714451.1	major capsid protein	-
MMC1_RS20425	3591307..3591972	-	666	WP_011714452.1	head decoration protein	-
MMC1_RS14805	3591987..3593219	-	1233	WP_041641268.1	S49 family peptidase	-
MMC1_RS14810	3593262..3593540	+	279	WP_011714454.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMC1_RS14815	3593553..3593840	+	288	WP_011714455.1	HigA family addiction module antidote protein	Antitoxin
MMC1_RS14820	3593860..3595344	-	1485	WP_011714456.1	phage portal protein	-
MMC1_RS14825	3595344..3595559	-	216	WP_011714457.1	hypothetical protein	-
MMC1_RS14830	3595563..3597419	-	1857	WP_011714458.1	phage terminase large subunit family protein	-
MMC1_RS14835	3597416..3597940	-	525	WP_011714459.1	hypothetical protein	-
MMC1_RS14840	3598037..3598234	+	198	WP_011714460.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3431648..3618608	186960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10718.37 Da
• Isoelectric Point: 9.0226

>T21779 WP_011714454.1 NC_008576:3593262-3593540 [Magnetococcus marinus MC-1]
MIISFRDKATESLYAGERVKKFVAFSKIALRKLDMLDAAVQLNDLRIPPGNRLEALKHDRVGQHSIRINDQWRICFVWKD
DGAHQVEIVDYH

Nucleotide

• Length: 279 bp

>T21779 NC_008576:3593262-3593540 [Magnetococcus marinus MC-1]
ATGATCATTAGCTTCCGAGACAAAGCGACTGAGTCGCTCTATGCAGGGGAAAGGGTGAAGAAGTTTGTTGCCTTCTCCAA
AATTGCCTTACGCAAGCTGGATATGTTGGATGCTGCGGTGCAACTGAATGACCTGCGTATTCCACCCGGGAACCGATTGG
AAGCGTTGAAGCATGATCGGGTGGGACAGCACTCGATCCGCATCAATGATCAGTGGCGCATCTGCTTTGTTTGGAAAGAT
GATGGCGCACACCAAGTTGAGATTGTTGACTACCACTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10456.06 Da
• Isoelectric Point: 8.6409

>AT21779 WP_011714455.1 NC_008576:3593553-3593840 [Magnetococcus marinus MC-1]
MRVKTHPGEILKEEFLVPMGMSANALSIALRVPATRISEIIRGRRGISAETALRLARYFGTTPQFWMNLQQAYDLSLAET
SVGESISNEIAPHAA

Nucleotide

• Length: 288 bp

>AT21779 NC_008576:3593553-3593840 [Magnetococcus marinus MC-1]
ATGCGCGTCAAAACCCACCCTGGTGAAATCCTCAAAGAGGAGTTCCTTGTACCCATGGGCATGAGTGCCAATGCGCTTTC
CATTGCGTTGCGTGTCCCCGCTACCCGAATCAGTGAAATTATTCGTGGACGGCGAGGCATCAGCGCTGAGACAGCGCTGC
GGTTAGCACGATATTTTGGTACAACACCCCAGTTTTGGATGAACCTGCAACAGGCCTATGATCTATCTCTTGCAGAAACA
TCTGTAGGCGAGTCCATCTCAAATGAGATCGCTCCTCATGCCGCCTAA

Structures

Toxin

• AlphaFold DB: A0LBP3