Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2088582..2089096 Replicon chromosome
Accession NZ_CP083911
Organism Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)


Gene name yoeB Uniprot ID A0A554XEH1
Locus tag LCC91_RS09880 Protein ID WP_043703736.1
Coordinates 2088830..2089096 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A554XEB7
Locus tag LCC91_RS09875 Protein ID WP_043703737.1
Coordinates 2088582..2088833 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCC91_RS09845 (LCC91_09845) 2083698..2084651 - 954 WP_043703746.1 ACP S-malonyltransferase -
LCC91_RS09850 (LCC91_09850) 2084691..2085710 - 1020 WP_043703744.1 beta-ketoacyl-ACP synthase III -
LCC91_RS09855 (LCC91_09855) 2085750..2086802 - 1053 WP_043703742.1 phosphate acyltransferase PlsX -
LCC91_RS09860 (LCC91_09860) 2086863..2087045 - 183 WP_043703740.1 50S ribosomal protein L32 -
LCC91_RS09865 (LCC91_09865) 2087151..2087801 - 651 WP_043703739.1 DUF177 domain-containing protein -
LCC91_RS09870 (LCC91_09870) 2087860..2088495 + 636 WP_043703738.1 pyridoxamine 5'-phosphate oxidase -
LCC91_RS09875 (LCC91_09875) 2088582..2088833 + 252 WP_043703737.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LCC91_RS09880 (LCC91_09880) 2088830..2089096 + 267 WP_043703736.1 Txe/YoeB family addiction module toxin Toxin
LCC91_RS09885 (LCC91_09885) 2089100..2089564 - 465 WP_052231842.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase -
LCC91_RS09890 (LCC91_09890) 2089557..2091185 - 1629 WP_043703733.1 polynucleotide adenylyltransferase PcnB -
LCC91_RS09895 (LCC91_09895) 2091182..2091901 - 720 WP_185974851.1 HAD family hydrolase -
LCC91_RS09900 (LCC91_09900) 2091930..2092619 - 690 WP_043703731.1 DnaA regulatory inactivator Hda -
LCC91_RS09905 (LCC91_09905) 2092622..2093722 - 1101 WP_052231812.1 AI-2E family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10472.95 Da        Isoelectric Point: 9.6396

>T217788 WP_043703736.1 NZ_CP083911:2088830-2089096 [Tepidimonas taiwanensis]
MKLIFAAAAWDDYLYWQRHDRRIVERINTLIRDVQRSPYAGIGKPEPLKHALSGYWSRRITDEHRMVYRVEGDAVLIAQL
RYHYGPSD

Download         Length: 267 bp

>T217788 NZ_CP114801:3842949-3843290 [Citrobacter sp. 21OH12SH02A-Citro]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTAGCACCCGTGGCTGTCTGGCAAATGCTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.41 Da        Isoelectric Point: 4.7023

>AT217788 WP_043703737.1 NZ_CP083911:2088582-2088833 [Tepidimonas taiwanensis]
MDVITYSAARANLARTMDRVCNDHAPLIITRNREQAVVMLSLEDYNALEETAYLLRSPANAQRLLNAIQELNAGGGTERQ
LAE

Download         Length: 252 bp

>AT217788 NZ_CP114801:3842611-3842928 [Citrobacter sp. 21OH12SH02A-Citro]
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCATATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554XEH1

Antitoxin

Source ID Structure
AlphaFold DB A0A554XEB7

References