Detailed information of TA system TA021778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3459962..3460595
• Replicon: chromosome
• Accession: NC_008576
• Organism: Magnetococcus marinus MC-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0LB84
• Locus tag: MMC1_RS13975
• Protein ID: WP_011714315.1
• Coordinates: 3459962..3460288 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMC1_RS13980
• Protein ID: WP_011713001.1
• Coordinates: 3460281..3460595 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMC1_RS20335	3455991..3456356	-	366	WP_011714313.1	hypothetical protein	-
MMC1_RS13970	3456364..3459915	-	3552	WP_011714314.1	phage tail tape measure protein	-
MMC1_RS13975	3459962..3460288	+	327	WP_011714315.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMC1_RS13980	3460281..3460595	+	315	WP_011713001.1	helix-turn-helix domain-containing protein	Antitoxin
MMC1_RS13985	3460664..3461056	-	393	WP_011714316.1	hypothetical protein	-
MMC1_RS20340	3461062..3461802	-	741	WP_011714317.1	hypothetical protein	-
MMC1_RS13995	3461808..3462218	-	411	WP_011714318.1	hypothetical protein	-
MMC1_RS14000	3462220..3462591	-	372	WP_011714319.1	hypothetical protein	-
MMC1_RS14005	3462594..3463511	-	918	WP_011714320.1	hypothetical protein	-
MMC1_RS14010	3463523..3463780	-	258	WP_011714321.1	hypothetical protein	-
MMC1_RS14015	3463783..3464100	-	318	WP_011714322.1	hypothetical protein	-
MMC1_RS14020	3464103..3465116	-	1014	WP_011714323.1	major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3413069..3502859	89790
	-	inside	Prophage	-	-	3431648..3618608	186960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-98)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12480.63 Da
• Isoelectric Point: 10.5272

>T21778 WP_011714315.1 NC_008576:3459962-3460288 [Magnetococcus marinus MC-1]
MKWSITFYNVNVQQEIRSWPVGIHADFLRLVQLLEEFGMDLRMPHSRAMGKGLFELRCKGSEGIGRAFYCTVKGQNIVIL
HSFIKKTQETPAKELRTAQKRLKEVKNG

Nucleotide

• Length: 327 bp

>T21778 NC_008576:3459962-3460288 [Magnetococcus marinus MC-1]
ATGAAATGGTCGATCACTTTTTACAATGTGAACGTGCAGCAGGAGATCCGCTCCTGGCCTGTTGGTATTCACGCTGATTT
TCTTCGCTTGGTCCAACTGCTGGAGGAGTTCGGCATGGACCTGCGCATGCCCCATTCCCGTGCCATGGGAAAAGGATTGT
TTGAATTGCGCTGCAAAGGGTCAGAGGGCATTGGTCGAGCGTTTTACTGCACGGTCAAAGGGCAGAACATTGTGATTCTT
CACTCGTTTATCAAGAAAACCCAAGAGACCCCTGCGAAAGAGCTGCGTACTGCGCAGAAACGTCTCAAGGAGGTAAAAAA
TGGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11500.17 Da
• Isoelectric Point: 8.9247

>AT21778 WP_011713001.1 NC_008576:3460281-3460595 [Magnetococcus marinus MC-1]
MADGYNPLPLNIKDELTHARLKPGFSEAYDALEDEFQALRTFLSARKEAGLTQEEIAKRMGTTKSAVSRLESSLGDHKHS
PSIATLRKYAKAVGCKLEIKLVPQ

Nucleotide

• Length: 315 bp

>AT21778 NC_008576:3460281-3460595 [Magnetococcus marinus MC-1]
ATGGCTGATGGCTACAACCCTCTTCCCCTCAATATTAAGGACGAGTTAACCCACGCCCGACTGAAGCCGGGCTTTAGTGA
GGCCTATGATGCTTTGGAAGATGAGTTCCAGGCTTTACGAACCTTCCTGTCGGCCCGCAAGGAAGCAGGACTTACCCAGG
AAGAGATTGCCAAACGAATGGGCACCACCAAAAGTGCCGTATCCCGTCTGGAATCTTCCCTGGGCGATCATAAACACTCT
CCATCTATTGCCACTCTGCGTAAATATGCCAAAGCGGTTGGCTGTAAATTGGAGATCAAGCTGGTTCCTCAGTAA

Structures

Toxin

• AlphaFold DB: A0LB84