Detailed information of TA system TA021776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3271862..3272495
• Replicon: chromosome
• Accession: NC_008576
• Organism: Magnetococcus marinus MC-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0L7A5
• Locus tag: MMC1_RS13100
• Protein ID: WP_011713002.1
• Coordinates: 3271862..3272188 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMC1_RS13105
• Protein ID: WP_011713001.1
• Coordinates: 3272181..3272495 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMC1_RS20280	3267891..3268256	-	366	WP_011714179.1	hypothetical protein	-
MMC1_RS13095	3268264..3271815	-	3552	WP_011714180.1	phage tail tape measure protein	-
MMC1_RS13100	3271862..3272188	+	327	WP_011713002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMC1_RS13105	3272181..3272495	+	315	WP_011713001.1	helix-turn-helix domain-containing protein	Antitoxin
MMC1_RS13110	3272564..3272956	-	393	WP_011714181.1	hypothetical protein	-
MMC1_RS20285	3272962..3273702	-	741	WP_011714182.1	hypothetical protein	-
MMC1_RS13120	3273708..3274118	-	411	WP_011714183.1	hypothetical protein	-
MMC1_RS13125	3274120..3274491	-	372	WP_011714184.1	hypothetical protein	-
MMC1_RS13130	3274494..3275411	-	918	WP_011712996.1	hypothetical protein	-
MMC1_RS13135	3275423..3275680	-	258	WP_011712995.1	hypothetical protein	-
MMC1_RS13140	3275683..3276000	-	318	WP_011714185.1	hypothetical protein	-
MMC1_RS13145	3276003..3277016	-	1014	WP_011712993.1	major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3259207..3325385	66178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-98)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12467.63 Da
• Isoelectric Point: 10.5272

>T21776 WP_011713002.1 NC_008576:3271862-3272188 [Magnetococcus marinus MC-1]
MKWSITFYNVNVQQEIRSWPVGIHADFLRLVQLLEEFGMDLRMPHSRAMGKGLFELRCKGSEGIGRAFYCTVKGQTIVIL
HSFIKKTQETPAKELRTAQKRLKEVKNG

Nucleotide

• Length: 327 bp

>T21776 NC_008576:3271862-3272188 [Magnetococcus marinus MC-1]
ATGAAATGGTCGATCACTTTTTACAATGTGAACGTGCAGCAGGAGATCCGCTCCTGGCCTGTTGGTATTCACGCTGATTT
TCTTCGCTTGGTCCAACTGCTGGAGGAGTTCGGCATGGACCTGCGCATGCCCCATTCCCGTGCCATGGGAAAAGGATTGT
TTGAATTGCGCTGCAAAGGGTCAGAGGGCATTGGTCGAGCGTTTTACTGCACGGTCAAAGGGCAGACCATTGTGATCCTG
CACTCGTTTATCAAGAAAACCCAAGAGACCCCTGCGAAAGAGCTGCGTACTGCGCAGAAACGTCTCAAGGAGGTGAAAAA
TGGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11500.17 Da
• Isoelectric Point: 8.9247

>AT21776 WP_011713001.1 NC_008576:3272181-3272495 [Magnetococcus marinus MC-1]
MADGYNPLPLNIKDELTHARLKPGFSEAYDALEDEFQALRTFLSARKEAGLTQEEIAKRMGTTKSAVSRLESSLGDHKHS
PSIATLRKYAKAVGCKLEIKLVPQ

Nucleotide

• Length: 315 bp

>AT21776 NC_008576:3272181-3272495 [Magnetococcus marinus MC-1]
ATGGCTGATGGCTACAACCCTCTTCCCCTCAATATTAAGGACGAGTTAACCCACGCCCGACTGAAGCCGGGCTTTAGTGA
GGCCTATGATGCTTTGGAAGATGAGTTCCAGGCTTTACGAACCTTCCTGTCGGCCCGCAAGGAAGCAGGGCTTACCCAGG
AAGAGATTGCCAAACGAATGGGCACCACCAAAAGTGCCGTATCCCGTCTGGAATCTTCCCTGGGCGATCATAAACACTCT
CCATCTATTGCCACTCTGCGTAAATATGCCAAAGCGGTTGGCTGTAAGTTGGAGATCAAGCTGGTTCCTCAGTAA

Structures

Toxin

• AlphaFold DB: A0L7A5