Detailed information of TA system TA021775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1620798..1621431
• Replicon: chromosome
• Accession: NC_008576
• Organism: Magnetococcus marinus MC-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0L7A5
• Locus tag: MMC1_RS06840
• Protein ID: WP_011713002.1
• Coordinates: 1621105..1621431 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMC1_RS06835
• Protein ID: WP_011713001.1
• Coordinates: 1620798..1621112 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMC1_RS06790	1616065..1617078	+	1014	WP_011712993.1	major capsid protein	-
MMC1_RS06795	1617081..1617398	+	318	WP_011712994.1	hypothetical protein	-
MMC1_RS06800	1617401..1617658	+	258	WP_011712995.1	hypothetical protein	-
MMC1_RS06805	1617670..1618587	+	918	WP_011712996.1	hypothetical protein	-
MMC1_RS06810	1618590..1618949	+	360	WP_011712997.1	hypothetical protein	-
MMC1_RS06815	1618951..1619355	+	405	WP_011712998.1	hypothetical protein	-
MMC1_RS06820	1619328..1619525	-	198	WP_041640935.1	hypothetical protein	-
MMC1_RS06825	1619591..1620331	+	741	WP_011712999.1	hypothetical protein	-
MMC1_RS06830	1620337..1620729	+	393	WP_011713000.1	hypothetical protein	-
MMC1_RS06835	1620798..1621112	-	315	WP_011713001.1	helix-turn-helix domain-containing protein	Antitoxin
MMC1_RS06840	1621105..1621431	-	327	WP_011713002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMC1_RS06845	1621478..1625029	+	3552	WP_011713003.1	phage tail tape measure protein	-
MMC1_RS06850	1625037..1625402	+	366	WP_011713004.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1528392..1625029	96637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-98)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12467.63 Da
• Isoelectric Point: 10.5272

>T21775 WP_011713002.1 NC_008576:c1621431-1621105 [Magnetococcus marinus MC-1]
MKWSITFYNVNVQQEIRSWPVGIHADFLRLVQLLEEFGMDLRMPHSRAMGKGLFELRCKGSEGIGRAFYCTVKGQTIVIL
HSFIKKTQETPAKELRTAQKRLKEVKNG

Nucleotide

• Length: 327 bp

>T21775 NC_008576:c1621431-1621105 [Magnetococcus marinus MC-1]
ATGAAATGGTCGATCACTTTTTACAATGTGAACGTGCAGCAGGAGATCCGCTCCTGGCCTGTTGGTATTCACGCTGATTT
TCTTCGCTTGGTCCAACTGCTGGAGGAGTTCGGCATGGACCTGCGCATGCCCCATTCCCGTGCCATGGGAAAAGGATTGT
TTGAATTGCGCTGCAAAGGGTCAGAGGGCATTGGTCGAGCGTTTTACTGCACGGTCAAAGGGCAGACCATTGTGATCCTG
CACTCGTTTATCAAGAAAACCCAAGAGACCCCTGCGAAAGAGCTGCGTACTGCGCAGAAACGTCTCAAGGAGGTGAAAAA
TGGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11500.17 Da
• Isoelectric Point: 8.9247

>AT21775 WP_011713001.1 NC_008576:c1621112-1620798 [Magnetococcus marinus MC-1]
MADGYNPLPLNIKDELTHARLKPGFSEAYDALEDEFQALRTFLSARKEAGLTQEEIAKRMGTTKSAVSRLESSLGDHKHS
PSIATLRKYAKAVGCKLEIKLVPQ

Nucleotide

• Length: 315 bp

>AT21775 NC_008576:c1621112-1620798 [Magnetococcus marinus MC-1]
ATGGCTGATGGCTACAACCCTCTTCCCCTCAATATTAAGGACGAGTTAACCCACGCCCGACTGAAGCCGGGCTTTAGTGA
GGCCTATGATGCTTTGGAAGATGAGTTCCAGGCTTTACGAACCTTCCTGTCGGCCCGCAAGGAAGCAGGGCTTACCCAGG
AAGAGATTGCCAAACGAATGGGCACCACCAAAAGTGCCGTATCCCGTCTGGAATCTTCCCTGGGCGATCATAAACACTCT
CCATCTATTGCCACTCTGCGTAAATATGCCAAAGCGGTTGGCTGTAAGTTGGAGATCAAGCTGGTTCCTCAGTAA

Structures

Toxin

• AlphaFold DB: A0L7A5