Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1819399..1819901 | Replicon | chromosome |
| Accession | NZ_CP083888 | ||
| Organism | Escherichia coli strain NDM1 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LCE25_RS08650 | Protein ID | WP_000767829.1 |
| Coordinates | 1819647..1819901 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LCE25_RS08645 | Protein ID | WP_001259255.1 |
| Coordinates | 1819399..1819650 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCE25_RS08620 (1814577) | 1814577..1815644 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| LCE25_RS08625 (1815644) | 1815644..1816714 | - | 1071 | WP_001362957.1 | histidinol-phosphate transaminase | - |
| LCE25_RS08630 (1816711) | 1816711..1818015 | - | 1305 | WP_001774536.1 | histidinol dehydrogenase | - |
| LCE25_RS08635 (1818021) | 1818021..1818920 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LCE25_RS08640 (1819066) | 1819066..1819116 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| LCE25_RS08645 (1819399) | 1819399..1819650 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LCE25_RS08650 (1819647) | 1819647..1819901 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LCE25_RS08655 (1819984) | 1819984..1820808 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| LCE25_RS08660 (1820854) | 1820854..1821783 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LCE25_RS08665 (1821998) | 1821998..1822060 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LCE25_RS08670 (1822050) | 1822050..1823408 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LCE25_RS08675 (1823587) | 1823587..1824645 | + | 1059 | WP_000492315.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LCE25_RS08680 (1824659) | 1824659..1824886 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T217749 WP_000767829.1 NZ_CP083888:1819647-1819901 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T217749 NZ_CP114771:c418081-417827 [Endozoicomonas sp. GU-1]
ATGAAAAAGAAACATGCCACGACACTGCGCAAACTGTTTGCCAGACCAGTCAGCGGCAGCATTCACTGGGCCGATATTGA
AAGCTTATTTCTGGGCCTTGGTGCCAAAGTTGAAGAACGTGAAGGCAGCCGGATCAAGGTGGTACTGTTTGGTGAGGTAA
GGATCTTTCACCGCCCACATCCGTCACCGGATACCGACAAGGGCGCGGTGGCCAGTATCCGCCGGTGGCTGGAGAACCAC
GGAGTGACGCCATGA
ATGAAAAAGAAACATGCCACGACACTGCGCAAACTGTTTGCCAGACCAGTCAGCGGCAGCATTCACTGGGCCGATATTGA
AAGCTTATTTCTGGGCCTTGGTGCCAAAGTTGAAGAACGTGAAGGCAGCCGGATCAAGGTGGTACTGTTTGGTGAGGTAA
GGATCTTTCACCGCCCACATCCGTCACCGGATACCGACAAGGGCGCGGTGGCCAGTATCCGCCGGTGGCTGGAGAACCAC
GGAGTGACGCCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT217749 WP_001259255.1 NZ_CP083888:1819399-1819650 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT217749 NZ_CP114771:c417830-417498 [Endozoicomonas sp. GU-1]
ATGATTAACCAGATGAACATCAACGGCTATACCGCCATCATTACTTACGACCCGGACATTGATCTGTTTCGGGGCGAGTT
TATTGGCCTGAACGGCGGCGCAGATTTTTACGCGGCGGATGTCAAAAGCCTGCACCAGGAAGGCAAGGTCTCCCTGAAAG
TGTTTCTGGAGGCCTGTCAGGAGGAAGGCATAGAGCCACGCAAGTCTTTCTCCGGCAAGCTGAACCTGCGTATTGACCCG
GATCTGCACGAATCCGCCAGTGTGGCAGCAGCGGCCAGTAACCGCAGTTTGAATCAGTTTATTAATGATGCATTGCGCCA
GAGCCTGAATTAA
ATGATTAACCAGATGAACATCAACGGCTATACCGCCATCATTACTTACGACCCGGACATTGATCTGTTTCGGGGCGAGTT
TATTGGCCTGAACGGCGGCGCAGATTTTTACGCGGCGGATGTCAAAAGCCTGCACCAGGAAGGCAAGGTCTCCCTGAAAG
TGTTTCTGGAGGCCTGTCAGGAGGAAGGCATAGAGCCACGCAAGTCTTTCTCCGGCAAGCTGAACCTGCGTATTGACCCG
GATCTGCACGAATCCGCCAGTGTGGCAGCAGCGGCCAGTAACCGCAGTTTGAATCAGTTTATTAATGATGCATTGCGCCA
GAGCCTGAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|