Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721792..722485 Replicon chromosome
Accession NZ_CP083888
Organism Escherichia coli strain NDM1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LCE25_RS03520 Protein ID WP_000415584.1
Coordinates 721792..722088 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LCE25_RS03525 Protein ID WP_000650107.1
Coordinates 722090..722485 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE25_RS03490 (717467) 717467..717781 - 315 WP_000958598.1 putative quinol monooxygenase -
LCE25_RS03495 (717812) 717812..718393 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LCE25_RS03500 (718503) 718503..719852 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
LCE25_RS03505 (719849) 719849..720508 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
LCE25_RS03510 (720660) 720660..721052 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LCE25_RS03515 (721105) 721105..721587 + 483 WP_000183494.1 GyrI-like domain-containing protein -
LCE25_RS03520 (721792) 721792..722088 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LCE25_RS03525 (722090) 722090..722485 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LCE25_RS03530 (722618) 722618..724225 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
LCE25_RS03535 (724363) 724363..726621 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 710065..722485 12420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217744 WP_000415584.1 NZ_CP083888:721792-722088 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217744 NZ_CP114761:c5157347-5157000 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217744 WP_000650107.1 NZ_CP083888:722090-722485 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217744 NZ_CP114761:c5157608-5157357 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References