Detailed information of TA system TA217698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2404946..2405584
• Replicon: chromosome
• Accession: NZ_CP083880
• Organism: Escherichia coli strain NDM3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: LCE26_RS11575
• Protein ID: WP_001447010.1
• Coordinates: 2405408..2405584 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LCE26_RS11570
• Protein ID: WP_001270286.1
• Coordinates: 2404946..2405362 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCE26_RS11550 (2400098)	2400098..2401039	-	942	WP_001251304.1	ABC transporter permease	-
LCE26_RS11555 (2401040)	2401040..2402053	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
LCE26_RS11560 (2402071)	2402071..2403216	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
LCE26_RS11565 (2403461)	2403461..2404867	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
LCE26_RS11570 (2404946)	2404946..2405362	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
LCE26_RS11575 (2405408)	2405408..2405584	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
LCE26_RS11580 (2405806)	2405806..2406036	+	231	WP_000494244.1	YncJ family protein	-
LCE26_RS11585 (2406128)	2406128..2408089	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
LCE26_RS11590 (2408162)	2408162..2408698	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
LCE26_RS11595 (2408790)	2408790..2409965	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP020543 Escherichia coli C IS/Tn TA075073 2433298..2434446 0.008	flank	IS/Tn	-	-	2410005..2411153	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T217698 WP_001447010.1 NZ_CP083880:c2405584-2405408 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T217698 NZ_CP114590:1503208-1503531 [Salinivibrio kushneri]
ATGCACTGGAACATTGTTTTTTACCGAGGCGTAGAAGAGAGCATTCTCAACATGCCTCCTAAGATTCAAGCGCGAATGCT
CAAGCTGCTCGAACTAATAGAAAAACATGGCGCAAACTTGGGTCCTCCTCACACAGAATCAATAGGTAACGGCCTGTTTG
AAATTCGCGCCAAAGCAAAAGAGGGAATCGGACGAAGTCTATTCTGTTATTTAGACGGTCCCAACATCTATATCCTTCAC
GCATTTGTGAAGAAAAGCCAAAAGACACCAAAGAGAGACTTAGCATTGGCAACAGGGCGTATGAAAGAGGTGAAAAGTGA
ATAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT217698 WP_001270286.1 NZ_CP083880:c2405362-2404946 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT217698 NZ_CP114590:1503524-1503808 [Salinivibrio kushneri]
GTGAATAGCTTACAGGCATTAAAAGCGAGAGCATTACAAAACCCAGACGTGAAACAAGCATATGATGAATTGGCGCCTGA
GTTTGAATTGATCGATATGTTACTCAGTATGCGTAAGCAGGCCGGGCTAACTCAACAGCAGGTTGCAGAACGTATGGGGA
CGAAAGAAGGTAATATTTCTCGACTTGAAAAAGGGAAAAGTAATCCAACCCTTAAAACCCTGATTAGCTATGCAAAAGCA
TGCAATTGCACGCTTAACTTTGGCTACAAACATGCGTCAAATTGA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8