Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2404946..2405584 Replicon chromosome
Accession NZ_CP083880
Organism Escherichia coli strain NDM3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LCE26_RS11575 Protein ID WP_001447010.1
Coordinates 2405408..2405584 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCE26_RS11570 Protein ID WP_001270286.1
Coordinates 2404946..2405362 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE26_RS11550 (2400098) 2400098..2401039 - 942 WP_001251304.1 ABC transporter permease -
LCE26_RS11555 (2401040) 2401040..2402053 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LCE26_RS11560 (2402071) 2402071..2403216 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LCE26_RS11565 (2403461) 2403461..2404867 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LCE26_RS11570 (2404946) 2404946..2405362 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LCE26_RS11575 (2405408) 2405408..2405584 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LCE26_RS11580 (2405806) 2405806..2406036 + 231 WP_000494244.1 YncJ family protein -
LCE26_RS11585 (2406128) 2406128..2408089 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LCE26_RS11590 (2408162) 2408162..2408698 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LCE26_RS11595 (2408790) 2408790..2409965 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2410005..2411153 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T217698 WP_001447010.1 NZ_CP083880:c2405584-2405408 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T217698 NZ_CP114590:1503208-1503531 [Salinivibrio kushneri]
ATGCACTGGAACATTGTTTTTTACCGAGGCGTAGAAGAGAGCATTCTCAACATGCCTCCTAAGATTCAAGCGCGAATGCT
CAAGCTGCTCGAACTAATAGAAAAACATGGCGCAAACTTGGGTCCTCCTCACACAGAATCAATAGGTAACGGCCTGTTTG
AAATTCGCGCCAAAGCAAAAGAGGGAATCGGACGAAGTCTATTCTGTTATTTAGACGGTCCCAACATCTATATCCTTCAC
GCATTTGTGAAGAAAAGCCAAAAGACACCAAAGAGAGACTTAGCATTGGCAACAGGGCGTATGAAAGAGGTGAAAAGTGA
ATAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT217698 WP_001270286.1 NZ_CP083880:c2405362-2404946 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT217698 NZ_CP114590:1503524-1503808 [Salinivibrio kushneri]
GTGAATAGCTTACAGGCATTAAAAGCGAGAGCATTACAAAACCCAGACGTGAAACAAGCATATGATGAATTGGCGCCTGA
GTTTGAATTGATCGATATGTTACTCAGTATGCGTAAGCAGGCCGGGCTAACTCAACAGCAGGTTGCAGAACGTATGGGGA
CGAAAGAAGGTAATATTTCTCGACTTGAAAAAGGGAAAAGTAATCCAACCCTTAAAACCCTGATTAGCTATGCAAAAGCA
TGCAATTGCACGCTTAACTTTGGCTACAAACATGCGTCAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References