Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1809991..1810493 Replicon chromosome
Accession NZ_CP083880
Organism Escherichia coli strain NDM3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LCE26_RS08635 Protein ID WP_000767832.1
Coordinates 1810239..1810493 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LCE26_RS08630 Protein ID WP_001259255.1
Coordinates 1809991..1810242 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE26_RS08605 (1805169) 1805169..1806236 - 1068 WP_000080064.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LCE26_RS08610 (1806236) 1806236..1807306 - 1071 WP_094336856.1 histidinol-phosphate transaminase -
LCE26_RS08615 (1807303) 1807303..1808607 - 1305 WP_024198577.1 histidinol dehydrogenase -
LCE26_RS08620 (1808613) 1808613..1809512 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LCE26_RS08625 (1809658) 1809658..1809708 - 51 WP_001364200.1 his operon leader peptide -
LCE26_RS08630 (1809991) 1809991..1810242 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LCE26_RS08635 (1810239) 1810239..1810493 + 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LCE26_RS08640 (1810576) 1810576..1811400 + 825 WP_000754737.1 SDR family oxidoreductase -
LCE26_RS08645 (1811446) 1811446..1812375 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LCE26_RS08650 (1812589) 1812589..1812651 + 63 WP_097433929.1 membrane protein YoeI -
LCE26_RS08655 (1812641) 1812641..1813999 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T217688 WP_000767832.1 NZ_CP083880:1810239-1810493 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T217688 NZ_CP114584:c1586819-1586502 [Salinivibrio proteolyticus]
TTGACGGCGAGCCAAATAAAAAAGCAGGTTCGTATTACGCCCAGAGCACGTGATGATCTTAAAAATATTGGTCGTTACAC
TGAGCGTAAATGGGGAAAAGCACAGCGTAACACTTATTTAAAGCGCCTAGCTACGCGGTTTAACTGGCTAGCAGAGAACC
CGCAACTAGGCCAGCATAGAACAGACATCGAAAACGGGTACTACTGCTTTCCTGAAGGACAACATCTTGTCTTTTATCTT
ATCCGACGCCATGCGATTGATATCATAGGTGTTCCTCATAAAGAAATGGACATTATTAACCATTTCACTATTGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT217688 WP_001259255.1 NZ_CP083880:1809991-1810242 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT217688 NZ_CP114584:c1587064-1586816 [Salinivibrio proteolyticus]
ATGGCAACAACAAGTTTAAGCTTAGGGGAGCACTGGGAAGTGTTTATTAAAAACGAGGTAGCAAGTGGCCGGTACGGCTC
TGCTAGCGAGGTTGTTCGTGATGCATTACGCACGCTTGAGGAACGCAAAACCAAATTGGATGTGTTGCGCGCACATCTTG
ATGAGGGGGCTAAACAGGCAGCCAGTGACACGTTTATCGATGACTTTTCAATGGATGAACTGATTAACGACTTGGACGCA
GAATCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References