Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 753750..754443 Replicon chromosome
Accession NZ_CP083880
Organism Escherichia coli strain NDM3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LCE26_RS03675 Protein ID WP_000415584.1
Coordinates 753750..754046 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LCE26_RS03680 Protein ID WP_000650107.1
Coordinates 754048..754443 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE26_RS03640 (748838) 748838..749152 - 315 WP_000958598.1 putative quinol monooxygenase -
LCE26_RS03645 (749183) 749183..749764 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LCE26_RS03650 (750083) 750083..750415 + 333 WP_023149630.1 DUF2645 family protein -
LCE26_RS03655 (750461) 750461..751810 - 1350 WP_224434072.1 quorum sensing histidine kinase QseC -
LCE26_RS03660 (751807) 751807..752466 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LCE26_RS03665 (752618) 752618..753010 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LCE26_RS03670 (753063) 753063..753545 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LCE26_RS03675 (753750) 753750..754046 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LCE26_RS03680 (754048) 754048..754443 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LCE26_RS03685 (754575) 754575..756182 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LCE26_RS03690 (756320) 756320..758578 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217685 WP_000415584.1 NZ_CP083880:753750-754046 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217685 NZ_CP114584:940720-941019 [Salinivibrio proteolyticus]
ATGGCTCAAATAGTTTGGACTGAGCCTGCGTTGGCAGATCTGAATGACGTTGCTGAATATGTTGCACTGGACAACCTGGT
TGCAGCTAAAGCGCTAGTGCAAGCGGCCTTTACCGCAGTGGAGCGGTTAGTGCTTTTTCCTGATTCTGGTCGAGTGCCAC
CTGAACTACCGCACTTGAATTATCGAGAGGTGGTGGTGAATCCTTGTCGTATTTTCTATAAGCAAGAAGAAGACACGGTG
TTTATCTTATTCGTCATGCGTTCAGAACAGGATCTACGTAAGTTCTTACTATCGCGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217685 WP_000650107.1 NZ_CP083880:754048-754443 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217685 NZ_CP114584:940475-940732 [Salinivibrio proteolyticus]
ATGAAAGTAGAACTTGTGACTACACTGAAGCGTCAGGCAACCAAAATTTTGTCTGAATTGAAGGCGAATAAAGAGCCTGT
TTTGATCACCGAACATGGTAAGCCTTCAGCATACTTATTAAGTGTGGATGATTACGAATTAATGCAGCGCCGTCTTGCTA
TCTTAGAAGGGATCGCGCGTGGCGAGCGCGCCATTACCGAAGAGAAGCTCTTGAGTCACCATGATGCCAAGGAACAAATG
TCCAGATGGCTCAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References