Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2404907..2405545 Replicon chromosome
Accession NZ_CP083877
Organism Escherichia coli strain NDM4

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LCE22_RS11575 Protein ID WP_001447010.1
Coordinates 2405369..2405545 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCE22_RS11570 Protein ID WP_001270286.1
Coordinates 2404907..2405323 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE22_RS11550 (2400066) 2400066..2401006 - 941 Protein_2257 ABC transporter permease -
LCE22_RS11555 (2401007) 2401007..2402019 - 1013 Protein_2258 ABC transporter ATP-binding protein -
LCE22_RS11560 (2402037) 2402037..2403179 - 1143 WP_224434039.1 ABC transporter substrate-binding protein -
LCE22_RS11565 (2403424) 2403424..2404828 - 1405 Protein_2260 PLP-dependent aminotransferase family protein -
LCE22_RS11570 (2404907) 2404907..2405323 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LCE22_RS11575 (2405369) 2405369..2405545 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LCE22_RS11580 (2405767) 2405767..2405997 + 231 WP_000494244.1 YncJ family protein -
LCE22_RS11585 (2406089) 2406089..2408050 - 1962 Protein_2264 23S rRNA 5-hydroxycytidine C2501 synthase -
LCE22_RS11590 (2408123) 2408123..2408659 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LCE22_RS11595 (2408751) 2408751..2409922 + 1172 Protein_2266 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2409962..2411110 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T217671 WP_001447010.1 NZ_CP083877:c2405545-2405369 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T217671 NZ_CP114571:c2391113-2390628 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAGCGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT217671 WP_001270286.1 NZ_CP083877:c2405323-2404907 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT217671 NZ_CP114571:c2391367-2391101 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References