Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2377486..2378124 Replicon chromosome
Accession NZ_CP083872
Organism Escherichia coli strain NDM5

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LCE27_RS11450 Protein ID WP_001447010.1
Coordinates 2377948..2378124 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCE27_RS11445 Protein ID WP_001270286.1
Coordinates 2377486..2377902 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE27_RS11425 (2372638) 2372638..2373579 - 942 WP_001251304.1 ABC transporter permease -
LCE27_RS11430 (2373580) 2373580..2374593 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LCE27_RS11435 (2374611) 2374611..2375756 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LCE27_RS11440 (2376001) 2376001..2377407 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LCE27_RS11445 (2377486) 2377486..2377902 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LCE27_RS11450 (2377948) 2377948..2378124 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LCE27_RS11455 (2378346) 2378346..2378576 + 231 WP_000494244.1 YncJ family protein -
LCE27_RS11460 (2378668) 2378668..2380629 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LCE27_RS11465 (2380702) 2380702..2381238 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LCE27_RS11470 (2381291) 2381291..2382505 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2382545..2383693 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T217642 WP_001447010.1 NZ_CP083872:c2378124-2377948 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T217642 NZ_CP114550:1192291-1192902 [Xylella fastidiosa subsp. pauca]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGCCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCAATTTTTGTGTGGCCTTGATGCTGAGGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACAGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGCGGATTGGC
TAGTATCATCCGCGATGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT217642 WP_001270286.1 NZ_CP083872:c2377902-2377486 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT217642 NZ_CP114550:1192106-1192294 [Xylella fastidiosa subsp. pauca]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References