Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 726303..726996 Replicon chromosome
Accession NZ_CP083872
Organism Escherichia coli strain NDM5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LCE27_RS03550 Protein ID WP_000415584.1
Coordinates 726303..726599 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LCE27_RS03555 Protein ID WP_000650107.1
Coordinates 726601..726996 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE27_RS03515 (721391) 721391..721705 - 315 WP_000958598.1 putative quinol monooxygenase -
LCE27_RS03520 (721736) 721736..722317 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LCE27_RS03525 (722636) 722636..722968 + 333 WP_023149630.1 DUF2645 family protein -
LCE27_RS03530 (723014) 723014..724363 - 1350 WP_224434072.1 quorum sensing histidine kinase QseC -
LCE27_RS03535 (724360) 724360..725019 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LCE27_RS03540 (725171) 725171..725563 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LCE27_RS03545 (725616) 725616..726098 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LCE27_RS03550 (726303) 726303..726599 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LCE27_RS03555 (726601) 726601..726996 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LCE27_RS03560 (727128) 727128..728735 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LCE27_RS03565 (728873) 728873..731131 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217629 WP_000415584.1 NZ_CP083872:726303-726599 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217629 NZ_CP114549:1197120-1197425 [Xylella fastidiosa subsp. pauca]
ATGAATAATGAGACGTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTAGCTAAGGCGCTTGGTTTACGGATGTCATTCACTCCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217629 WP_000650107.1 NZ_CP083872:726601-726996 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217629 NZ_CP114549:1196821-1197123 [Xylella fastidiosa subsp. pauca]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATATCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTGCTTTGCGGTGGCGATAAATCG
TCACAAATGCGAGATATCGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References