Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2402869..2403507 Replicon chromosome
Accession NZ_CP083869
Organism Escherichia coli strain NDM6

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LCE24_RS12910 Protein ID WP_001447010.1
Coordinates 2403331..2403507 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCE24_RS12905 Protein ID WP_001270286.1
Coordinates 2402869..2403285 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE24_RS12885 (2398021) 2398021..2398962 - 942 WP_001251304.1 ABC transporter permease -
LCE24_RS12890 (2398963) 2398963..2399976 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LCE24_RS12895 (2399994) 2399994..2401139 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LCE24_RS12900 (2401384) 2401384..2402790 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LCE24_RS12905 (2402869) 2402869..2403285 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LCE24_RS12910 (2403331) 2403331..2403507 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LCE24_RS12915 (2403729) 2403729..2403959 + 231 WP_000494244.1 YncJ family protein -
LCE24_RS12920 (2404051) 2404051..2406012 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LCE24_RS12925 (2406085) 2406085..2406621 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LCE24_RS12930 (2406713) 2406713..2407888 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2407928..2409076 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T217620 WP_001447010.1 NZ_CP083869:c2403507-2403331 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T217620 NZ_CP114542:c2753983-2753684 [Brevundimonas subvibrioides]
ATGAAGTTCGACTGGGATCCGGAAAAGGCCAAGGCAAATTTCGCCAAACACGGTGTCGCTTTCGACGTCGCCATGAGGGT
CTTCGACGATCCTCGATCCGTGACAGTGTTCGATCGTACCGTCGCCGGAGAAGAGCGCTGGAGGACTGTTGGTAGGGTAG
GCGTGGCGACCATTCTCTTCGTAGCCCACACCTGGCTGGACGAAGATGGCGAACTCTACGTCCGGATCATCTCGGCCCGT
CGGGCCGACAGACTGGAGATAAGAGCCTATGAAAGAGGCGACGAGGGACATTTCCGCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT217620 WP_001270286.1 NZ_CP083869:c2403285-2402869 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT217620 NZ_CP114542:c2753664-2753449 [Brevundimonas subvibrioides]
ATGCGCGACGAAGACATCGATTACAGCGATATTCCGCCGGTGCGCGATTGGTCGGGGGCCAAGCGCGGTCTGTTCTATCG
CCCCGAGAAGCAGGCCGTGACGATTCGCCTCGACGCCGACGTGGTCGCCTGGTTCAAGAGCGTGGAGCCGAAATACCAGA
CGGCCGTCAACCGTGTGTTGCGAGAGTATATGCTGGCCCACGCCAAGGCAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References