217619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2315905..2317493 Replicon chromosome
Accession NZ_CP083869
Organism Escherichia coli strain NDM6

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag LCE24_RS12545 Protein ID WP_001125439.1
Coordinates 2316171..2317493 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LCE24_RS12540 Protein ID WP_001301023.1
Coordinates 2315905..2316171 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE24_RS12540 (2315905) 2315905..2316171 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LCE24_RS12545 (2316171) 2316171..2317493 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LCE24_RS12550 (2317805) 2317805..2318013 + 209 Protein_2188 AraC family transcriptional regulator -
LCE24_RS12555 (2318268) 2318268..2319494 + 1227 Protein_2189 fimbria/pilus outer membrane usher protein -
LCE24_RS12560 (2319508) 2319508..2320038 + 531 WP_000876763.1 fimbrial protein -
LCE24_RS12565 (2320051) 2320051..2320554 + 504 WP_000825452.1 fimbrial protein -
LCE24_RS12570 (2320613) 2320613..2321527 + 915 WP_000520662.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2315905..2328714 12809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T217619 WP_001125439.1 NZ_CP083869:2316171-2317493 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T217619 NZ_CP114542:c2280090-2279701 [Brevundimonas subvibrioides]
TTGATCGTCGACAGTTCGGCGCTTGTCGCCATCCTGTTCAACGAGCCTGAAGCGGCGGAGTTCGCGCGTCTGATGATGCG
GGAACCATGCAGGATTTCTGCGGCAAACTACTTCGAGGCCGGTATGGTTGTGGATCGCAAGACCAGGGATGAAATCCCTC
GCCAGGCCTTCGACACCCTGGTTGCGACGACGCGTCTGGACATCGTGGACGTGACCCGCGAGCAGGCCGATGAAGCGCGG
ATGGCGTATCGCAGGTTCGGCAAGGGCTATCATGAGGCGCGCCTGAATTTCGGGGACTGCTTCGCCTATGTGCTGGCCAG
GCGGACCGGCGAACCCCTGCTGTTCAAGGGCGACGATTTCGCTCGCACCGATGTGGTCCGCGCGCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT217619 WP_001301023.1 NZ_CP083869:2315905-2316171 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT217619 NZ_CP114542:c2280341-2280087 [Brevundimonas subvibrioides]
ATGCTGAACATCAAGAACCCCGAGACACACAGGCTGGCCAGGGAGCTGGCGGCGCGGCGCGGCGAAAGCCTGACTACGGC
GGTCACCGTGGCCTTGCGGGAACAGCTGGCGCGCGAGCCGGTCGAGCCACCCAGTGCGACGGTGGAAGATATCATGGCGC
TGGTGCGGTCGATTCAGCCGCATCTGACCCCTCTGGAGCCCGGAGAGGATCCGACCGCGTTTCTCTACGATGACGAGACG
GGGCTACCGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References