Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1809970..1810472 Replicon chromosome
Accession NZ_CP083869
Organism Escherichia coli strain NDM6

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LCE24_RS09980 Protein ID WP_000767832.1
Coordinates 1810218..1810472 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LCE24_RS09975 Protein ID WP_001259255.1
Coordinates 1809970..1810221 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE24_RS09950 (1805148) 1805148..1806215 - 1068 WP_000080064.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LCE24_RS09955 (1806215) 1806215..1807285 - 1071 WP_094336856.1 histidinol-phosphate transaminase -
LCE24_RS09960 (1807282) 1807282..1808586 - 1305 WP_024198577.1 histidinol dehydrogenase -
LCE24_RS09965 (1808592) 1808592..1809491 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LCE24_RS09970 (1809637) 1809637..1809687 - 51 WP_001364200.1 his operon leader peptide -
LCE24_RS09975 (1809970) 1809970..1810221 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LCE24_RS09980 (1810218) 1810218..1810472 + 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LCE24_RS09985 (1810555) 1810555..1811379 + 825 WP_000754737.1 SDR family oxidoreductase -
LCE24_RS09990 (1811425) 1811425..1812354 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LCE24_RS09995 (1812568) 1812568..1812630 + 63 WP_097433929.1 membrane protein YoeI -
LCE24_RS10000 (1812620) 1812620..1813978 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T217610 WP_000767832.1 NZ_CP083869:1810218-1810472 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T217610 NZ_CP114523:117950-118201 [Ligilactobacillus salivarius]
ATGAATAAGAATTGGTCTGATGAAGCCTGGGATGACTACATGAGCTGGCAAAGTGATAAAAGAATAGTTAAGAAAATTAA
TAAGCTAATAAAAGATATTGATAGACATCCTTTTTCAGGAATAGGTAAACCAGAACCGTTAAAATATGGTTTATCAGGAA
CATGGTCTAGAAGAATTACGGAAGAGCATCGAATAGTCTATGAGATAAAAGATGATGAGATACGTATCTATTCTGTCAGA
GACCATTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT217610 WP_001259255.1 NZ_CP083869:1809970-1810221 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT217610 NZ_CP114523:117691-117957 [Ligilactobacillus salivarius]
ATGGAAGCTACAACATACTCTAATTTTAGAAAATCCCTTAAATCATTCATGAAACAAGTCAATGAAGATTCAGAACCTTT
AATTGTTACTAATAAAAATAAAGAAGAAGATATTGTTGTTATGGGTAAAGATGACTATGATTCGCTAGTCGAAACCATGA
GAATTATAGAAAATAAATATCTCTATAACAAGATAAGACGTGGCAGAGAACAATTAGATTCTAAAAGTAACTACCACGAT
TTAATCGAGGTTGATGGCGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References