Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 753745..754438 Replicon chromosome
Accession NZ_CP083869
Organism Escherichia coli strain NDM6

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LCE24_RS05020 Protein ID WP_000415584.1
Coordinates 753745..754041 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LCE24_RS05025 Protein ID WP_000650107.1
Coordinates 754043..754438 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE24_RS04985 (748833) 748833..749147 - 315 WP_000958598.1 putative quinol monooxygenase -
LCE24_RS04990 (749178) 749178..749759 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LCE24_RS04995 (750078) 750078..750410 + 333 WP_023149630.1 DUF2645 family protein -
LCE24_RS05000 (750456) 750456..751805 - 1350 WP_224434072.1 quorum sensing histidine kinase QseC -
LCE24_RS05005 (751802) 751802..752461 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LCE24_RS05010 (752613) 752613..753005 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LCE24_RS05015 (753058) 753058..753540 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LCE24_RS05020 (753745) 753745..754041 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LCE24_RS05025 (754043) 754043..754438 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LCE24_RS05030 (754570) 754570..756177 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LCE24_RS05035 (756315) 756315..758573 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217607 WP_000415584.1 NZ_CP083869:753745-754041 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217607 NZ_CP114518:117053-117304 [Ligilactobacillus salivarius]
ATGAATAAGAATTGGTCTGATGAAGCCTGGGATGACTACATGAGCTGGCAAAGTGATAAAAGAATAGTTAAGAAAATTAA
TAAGCTAATAAAAGATATTGATAGACATCCTTTTTCAGGAATAGGTAAACCAGAACCGTTAAAATATGGTTTATCAGGAA
CATGGTCTAGAAGAATTACGGAAGAGCATCGAATAGTCTATGAGATAAAAGATGATGAGATACGTATCTATTCTGTCAGA
GACCATTATTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217607 WP_000650107.1 NZ_CP083869:754043-754438 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217607 NZ_CP114518:116794-117060 [Ligilactobacillus salivarius]
ATGGAAGCTACAACATACTCTAATTTTAGAAAATCCCTTAAATCATTCATGAAACAAGTCAATGAAGATTCAGAACCTTT
AATTGTTACTAATAAAAATAAAGAAGAAGATATTGTTGTTATGGGTAAAGATGACTATGATTCGCTAGTCGAAACCATGA
GAATTATAGAAAATAAATATCTCTATAACAAGATAAGACGTGGCAGAGAACAATTAGATTCTAAAAGTAACTACCACGAT
TTAATCGAGGTTGATGGCGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References