Detailed information of TA system TA021752

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1468627..1468998
• Replicon: chromosome
• Accession: NC_008563
• Organism: Escherichia coli APEC O1

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: APECO1_RS07460
• Protein ID: WP_001317028.1
• Coordinates: 1468804..1468998 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1468627..1468805 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APECO1_RS31540	1464379..1464552	+	174	WP_001296046.1	hypothetical protein	-
APECO1_RS07435	1464582..1465955	+	1374	WP_000123782.1	ATP-dependent RNA helicase DbpA	-
APECO1_RS07440	1466084..1467019	-	936	WP_001157379.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
APECO1_RS28495	1467071..1468306	-	1236	WP_000040829.1	site-specific integrase	-
APECO1_RS07450	1468308..1468523	-	216	WP_000079604.1	excisionase XisR	-
APECO1_RS07455	1468623..1468811	-	189	WP_001302840.1	DUF1187 family protein	-
-	1468627..1468805	+	179	NuclAT_0	-	Antitoxin
-	1468627..1468805	+	179	NuclAT_0	-	Antitoxin
-	1468627..1468805	+	179	NuclAT_0	-	Antitoxin
-	1468627..1468805	+	179	NuclAT_0	-	Antitoxin
APECO1_RS07460	1468804..1468998	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
APECO1_RS07465	1469055..1469864	-	810	WP_000166319.1	recombination protein RecT	-
APECO1_RS07470	1469857..1472457	-	2601	WP_000105155.1	exodeoxyribonuclease VIII	-
APECO1_RS07475	1472559..1472834	-	276	WP_021542963.1	phage protein	-
APECO1_RS07480	1472909..1473085	-	177	WP_000245512.1	hypothetical protein	-
APECO1_RS07485	1473079..1473300	-	222	WP_000560230.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1467071..1511910	44839

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T21752 WP_001317028.1 NC_008563:c1468998-1468804 [Escherichia coli APEC O1]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T21752 NC_008563:c1468998-1468804 [Escherichia coli APEC O1]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT21752 NC_008563:1468627-1468805 [Escherichia coli APEC O1]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCCGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin