Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4813087..4813689 Replicon chromosome
Accession NZ_CP083834
Organism Enterobacter asburiae strain AR0468-yvys

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LCD48_RS23600 Protein ID WP_045888501.1
Coordinates 4813378..4813689 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LCD48_RS23595 Protein ID WP_045888502.1
Coordinates 4813087..4813377 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD48_RS23580 (LCD48_23585) 4810586..4811488 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
LCD48_RS23585 (LCD48_23590) 4811485..4812120 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
LCD48_RS23590 (LCD48_23595) 4812117..4813046 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
LCD48_RS23595 (LCD48_23600) 4813087..4813377 - 291 WP_045888502.1 NadS family protein Antitoxin
LCD48_RS23600 (LCD48_23605) 4813378..4813689 - 312 WP_045888501.1 hypothetical protein Toxin
LCD48_RS23605 (LCD48_23610) 4813838..4814779 - 942 WP_039264191.1 fatty acid biosynthesis protein FabY -
LCD48_RS23610 (LCD48_23615) 4814824..4815261 - 438 WP_045888500.1 D-aminoacyl-tRNA deacylase -
LCD48_RS23615 (LCD48_23620) 4815258..4816139 - 882 WP_045888499.1 virulence factor BrkB family protein -
LCD48_RS23620 (LCD48_23625) 4816133..4816732 - 600 WP_045888498.1 glucose-1-phosphatase -
LCD48_RS23625 (LCD48_23630) 4817137..4817913 + 777 WP_045888497.1 hypothetical protein -
LCD48_RS23630 (LCD48_23635) 4817916..4818200 + 285 WP_023309759.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12192.17 Da        Isoelectric Point: 9.7548

>T217509 WP_045888501.1 NZ_CP083834:c4813689-4813378 [Enterobacter asburiae]
MLFIETDIFTEDVKTLLDDDEYHRFQVFLATQPEFGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREYEIRLLLIY
RKGIKDDLSASEKAILKKMIERW

Download         Length: 312 bp

>T217509 NZ_CP114328:795335-795745 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTCCCCTGGCCGCTGAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGCACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10772.41 Da        Isoelectric Point: 11.0982

>AT217509 WP_045888502.1 NZ_CP083834:c4813377-4813087 [Enterobacter asburiae]
MDKALFERLTKSMAQMNEIAEGKREPSRTFQIDAIKIKEIRQASGLSQRKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT217509 NZ_CP114328:795088-795354 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References