Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 73997..74643 Replicon chromosome
Accession NZ_CP083815
Organism Enterobacter asburiae strain 161373-yvys

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LCD39_RS00340 Protein ID WP_033147058.1
Coordinates 74293..74643 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LCD39_RS00335 Protein ID WP_023309874.1
Coordinates 73997..74296 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD39_RS00310 (LCD39_00310) 69720..70481 + 762 WP_167819685.1 winged helix-turn-helix domain-containing protein -
LCD39_RS00315 (LCD39_00315) 70483..70962 + 480 WP_064673830.1 hypothetical protein -
LCD39_RS00320 (LCD39_00320) 71092..72090 + 999 WP_232938874.1 helix-turn-helix domain-containing protein -
LCD39_RS00325 (LCD39_00325) 72176..73174 + 999 WP_232938875.1 class I SAM-dependent methyltransferase -
LCD39_RS00330 (LCD39_00330) 73531..73968 + 438 WP_033147059.1 acetyltransferase -
LCD39_RS00335 (LCD39_00335) 73997..74296 - 300 WP_023309874.1 XRE family transcriptional regulator Antitoxin
LCD39_RS00340 (LCD39_00340) 74293..74643 - 351 WP_033147058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD39_RS00350 (LCD39_00350) 75469..76860 + 1392 WP_048980239.1 glycoside-pentoside-hexuronide family transporter -
LCD39_RS00355 (LCD39_00355) 76873..79191 + 2319 WP_246946844.1 alpha-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 68688..69656 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13561.65 Da        Isoelectric Point: 8.0081

>T217407 WP_033147058.1 NZ_CP083815:c74643-74293 [Enterobacter asburiae]
MWTVLFGKVFEQWLLEQEEGLQDKVLADLLNLQKYGPRLPRPYADTVKGSWYNHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKAFYEKMIRIADTEFSFHLTSLEATK

Download         Length: 351 bp

>T217407 NZ_CP114278:2910459-2910719 [Brevundimonas vesicularis]
ATGAAGCTGACCTTCCAGACCTACGGGTGGGAGGATTACCTTCACTGGCAAGACCATGATCGAAAGATGCTGCGAAAGCT
CAATCGGCTGATCATGGAATGCCAGCGGACGCCTTTTTCCGGGACTGGAAAACCTGAACCGTTGAAGGGCGATTTTTCGG
GATGGTGGTCGCGGCGCATCGACCAGGAACATCGGCTCGTCTATCGCGTGACCGACGATGCGCTTTTGATCGCCCAATGC
CGCTATCACTACGACCGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11165.99 Da        Isoelectric Point: 7.2052

>AT217407 WP_023309874.1 NZ_CP083815:c74296-73997 [Enterobacter asburiae]
VKTLNEVIASRSPESQQRIKEMADEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAMG
GKLHIDIELPTGKRVAFHI

Download         Length: 300 bp

>AT217407 NZ_CP114278:2910205-2910462 [Brevundimonas vesicularis]
ATGAACGCGATGTCCGTCACCGAACTCCGCAAGAACCTCGCCGCGGCCATCGACCGGGTGACGGCGGATCATGACTACAC
GATCATCACGCGCGAGGGCGGTAAGCCGGCGGCGGTGCTGATGTCGTTGGAGGACTTCGCCTCCTGGCAGGAGACGGAGT
ATCTACTGCGCAGCCCGGCGAACGCTGCGAGGTTGCGTGAGGCGATCTCCGAACTCGATGCGGGCGGCGGCCAGGTTCGC
GAACTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References