Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2431373..2431890 Replicon chromosome
Accession NZ_CP083805
Organism Staphylococcus argenteus strain 1801221

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag LB317_RS11740 Protein ID WP_031787172.1
Coordinates 2431373..2431639 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag LB317_RS11745 Protein ID WP_031787173.1
Coordinates 2431639..2431890 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB317_RS11715 (2426803) 2426803..2427339 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
LB317_RS11720 (2427572) 2427572..2428396 - 825 WP_000572040.1 formate/nitrite transporter family protein -
LB317_RS11725 (2428613) 2428613..2428798 - 186 WP_000230291.1 hypothetical protein -
LB317_RS11730 (2428882) 2428882..2429349 - 468 WP_031787170.1 SRPBCC domain-containing protein -
LB317_RS11735 (2429532) 2429532..2431076 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LB317_RS11740 (2431373) 2431373..2431639 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
LB317_RS11745 (2431639) 2431639..2431890 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LB317_RS11750 (2432162) 2432162..2432761 - 600 WP_000162802.1 DsbA family protein -
LB317_RS11755 (2432781) 2432781..2433143 - 363 WP_031787174.1 DUF4467 domain-containing protein -
LB317_RS11760 (2433397) 2433397..2434647 + 1251 WP_031787175.1 aminoacyltransferase -
LB317_RS11765 (2434742) 2434742..2435473 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
LB317_RS11770 (2435470) 2435470..2436189 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T217388 WP_031787172.1 NZ_CP083805:c2431639-2431373 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T217388 NZ_CP114195:c713566-713312 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGCTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCCTTAGATTACTACAATAGCCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT217388 WP_031787173.1 NZ_CP083805:c2431890-2431639 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT217388 NZ_CP114195:c713319-713050 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGACGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGTATCAATAAACTTATCAATGATGTTAAACGTTCTCCATTTGAGGGTATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCCCGTCGTGTTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGTCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References