Detailed information of TA system TA217384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1998096..1998403
• Replicon: chromosome
• Accession: NZ_CP083805
• Organism: Staphylococcus argenteus strain 1801221

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LB317_RS09470
• Protein ID: WP_011447039.1
• Coordinates: 1998227..1998403 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1998096..1998235 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB317_RS09430 (1993662)	1993662..1993841	+	180	WP_000669789.1	hypothetical protein	-
LB317_RS09435 (1994152)	1994152..1994412	+	261	WP_001791826.1	hypothetical protein	-
LB317_RS09440 (1994465)	1994465..1994815	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
LB317_RS09445 (1995326)	1995326..1995661	-	336	Protein_1822	SH3 domain-containing protein	-
LB317_RS09450 (1996312)	1996312..1996803	-	492	WP_000920035.1	staphylokinase	-
LB317_RS09455 (1996994)	1996994..1997749	-	756	WP_000861030.1	CHAP domain-containing protein	-
LB317_RS09460 (1997761)	1997761..1998015	-	255	WP_000611512.1	phage holin	-
LB317_RS09465 (1998067)	1998067..1998174	+	108	WP_001791821.1	hypothetical protein	-
- (1998096)	1998096..1998235	+	140	NuclAT_0	-	Antitoxin
- (1998096)	1998096..1998235	+	140	NuclAT_0	-	Antitoxin
- (1998096)	1998096..1998235	+	140	NuclAT_0	-	Antitoxin
- (1998096)	1998096..1998235	+	140	NuclAT_0	-	Antitoxin
LB317_RS09470 (1998227)	1998227..1998403	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
LB317_RS09475 (1998553)	1998553..1998849	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
LB317_RS09480 (1998907)	1998907..1999194	-	288	WP_001040256.1	hypothetical protein	-
LB317_RS09485 (1999241)	1999241..1999393	-	153	WP_001153681.1	hypothetical protein	-
LB317_RS09490 (1999383)	1999383..2003168	-	3786	WP_031788239.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1994465..2048370	53905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T217384 WP_011447039.1 NZ_CP083805:c1998403-1998227 [Staphylococcus argenteus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T217384 NZ_CP114191:c35551-35033 [Aminobacter sp. NyZ550]
ATGCCTGAAGCCGCCCTGCGTCAGCAGCGAACCTTGTGGCGGGCCTTCGTGCCGCGCTGGGCCCACATGCCGCTTTCGGG
CGAGGGCGCTGCGCGTTTCGGCGGGCGCTGGAACCCGGTAGGATCGCCGACGCTGTATGCGGCCTGTGAGCTGTCGACCG
CCTGGGCTGAATACAACCAGGGTTTTGTCCAGCATCCGGCGTTGATCGCCCAGCTCGAGCTGTCGGACGCGAGGCTGGCC
GACCTGACTGTTGCCGCGATTTTGGACGAACTCGGCATCGATGCCGGCATTCACAGATGCGAGTGGCGTTCCGATCTCGA
CGACGGCAGGGTACCGGAGACCCATCTGCTGCGGCAGCGCCTGCTCACCGAAGGCTTTGACGGCGTCGTCTATCCCTCGT
TCATGTCTCCCGGCGGCAGTTGCGTAGCATTGTGGCGCTGGAACGGTCCCGGCCAGCCATCACTCAAGATTATAGATCCT
GATCAGCGCCTGCCCAAGACGCAGGCCTCCTGGCTTTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT217384 NZ_CP083805:1998096-1998235 [Staphylococcus argenteus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin