Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1926340..1927603 Replicon chromosome
Accession NZ_CP083760
Organism Candidatus Sulfidibacterium hydrothermale isolate EPR1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LA303_RS07615 Protein ID WP_240524692.1
Coordinates 1926665..1927603 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag LA303_RS07610 Protein ID WP_240524691.1
Coordinates 1926340..1926663 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA303_RS07590 (LA303_07595) 1922995..1923651 + 657 WP_240524687.1 response regulator transcription factor -
LA303_RS07595 (LA303_07600) 1923816..1924640 + 825 WP_240524688.1 hypothetical protein -
LA303_RS07600 (LA303_07605) 1924668..1925891 + 1224 WP_240524689.1 ammonium transporter -
LA303_RS07605 (LA303_07610) 1926116..1926343 + 228 WP_240524690.1 type II toxin-antitoxin system Y4mF family antitoxin -
LA303_RS07610 (LA303_07615) 1926340..1926663 + 324 WP_240524691.1 HipA N-terminal domain-containing protein Antitoxin
LA303_RS07615 (LA303_07620) 1926665..1927603 + 939 WP_240524692.1 HipA domain-containing protein Toxin
LA303_RS07625 (LA303_07630) 1927928..1928944 + 1017 WP_240524693.1 glycosyltransferase family 2 protein -
LA303_RS07630 (LA303_07635) 1929012..1931099 - 2088 WP_240524694.1 prolyl oligopeptidase family serine peptidase -
LA303_RS07635 (LA303_07640) 1931184..1931618 - 435 WP_240524695.1 type II 3-dehydroquinate dehydratase -
LA303_RS07640 (LA303_07645) 1931666..1932358 + 693 WP_240524696.1 DUF434 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(54-277)

Antitoxin

HipA, N-terminal subdomain 1

(5-102)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35927.55 Da        Isoelectric Point: 9.2333

>T217265 WP_240524692.1 NZ_CP083760:1926665-1927603 [Candidatus Sulfidibacterium hydrothermale]
MENKCLYCYNKLNDALDFHPRCIKTFFGSTRAPLLPYTIDQMADLAKNVVQRSISVPGVQPKLSLSLIKAVGKKESRLTV
VGALDGNYILKPPHPNYPEMPQNEHLTMRMAEVFGIKVVPSSLIRLKSGELSYITKRIDRTDGGEKIHMIDMFQITEAFD
KYKSSMEKIGKAIESYSENPLLDKLFFFELTVFSFLTGNNDMHLKNFSMIKTDFGWVLSPAYDLLNATILNPDDDEELAL
TLEGRKKKLQRKHFEHFGYDLGLSTKQTNGVFKRFYKNKESAYKLIGQSFLSDDMKNRYWHLMEKRYDILSG

Download         Length: 939 bp

>T217265 NZ_CP114128:c2248928-2248821 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12264.17 Da        Isoelectric Point: 4.8226

>AT217265 WP_240524691.1 NZ_CP083760:1926340-1926663 [Candidatus Sulfidibacterium hydrothermale]
MRKAKVMYGNEIAGILTETDEGEYIFRYDENYVDQHPGQFITFTMPVTKEPYKSNRLFPFFEGLIPEGWLLNIASRSWKI
NPNDRMGLLLACCKDCIGAVSIVPIPE

Download         Length: 324 bp

>AT217265 NZ_CP114128:2248975-2249032 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References