Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1573982..1574494 Replicon chromosome
Accession NC_008533
Organism Streptococcus pneumoniae D39

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPD_RS08245 Protein ID WP_000924721.1
Coordinates 1573982..1574236 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPD_RS08250 Protein ID WP_000388572.1
Coordinates 1574240..1574494 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPD_RS08230 (SPD_1547) 1571083..1571397 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SPD_RS08235 (SPD_1548) 1571422..1572048 - 627 WP_000775044.1 guanylate kinase -
SPD_RS08240 (SPD_1549) 1572178..1573791 - 1614 WP_000404940.1 ribonuclease Y -
SPD_RS08245 (SPD_1550) 1573982..1574236 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPD_RS08250 (SPD_1551) 1574240..1574494 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPD_RS08255 (SPD_1552) 1574732..1575829 - 1098 WP_000156355.1 nucleotidyltransferase -
SPD_RS08260 (SPD_1553) 1575839..1576585 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
SPD_RS08265 (SPD_1554) 1576688..1577041 - 354 WP_001003001.1 ribosome silencing factor -
SPD_RS08270 (SPD_1555) 1577054..1577554 - 501 WP_000844717.1 cysteine hydrolase -
SPD_RS08275 (SPD_1556) 1577555..1578148 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPD_RS08280 (SPD_1557) 1578148..1578777 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SPD_RS08285 (SPD_1558) 1578829..1579140 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T21726 WP_000924721.1 NC_008533:c1574236-1573982 [Streptococcus pneumoniae D39]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T21726 NC_008533:c1574236-1573982 [Streptococcus pneumoniae D39]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT21726 WP_000388572.1 NC_008533:c1574494-1574240 [Streptococcus pneumoniae D39]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT21726 NC_008533:c1574494-1574240 [Streptococcus pneumoniae D39]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References