Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2599220..2599872 Replicon chromosome
Accession NZ_CP083754
Organism Serratia marcescens strain YL4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LBP97_RS12290 Protein ID WP_173888469.1
Coordinates 2599220..2599564 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LBP97_RS12295 Protein ID WP_025304078.1
Coordinates 2599570..2599872 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBP97_RS12275 (LBP97_12295) 2595013..2595567 + 555 WP_197836328.1 hypothetical protein -
LBP97_RS12280 (LBP97_12300) 2595539..2597821 - 2283 WP_197824432.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
LBP97_RS12285 (LBP97_12305) 2598042..2599061 + 1020 WP_028127674.1 HTH-type transcriptional regulator GalR -
LBP97_RS12290 (LBP97_12310) 2599220..2599564 + 345 WP_173888469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LBP97_RS12295 (LBP97_12315) 2599570..2599872 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
LBP97_RS12300 (LBP97_12320) 2599900..2601162 - 1263 WP_238968688.1 diaminopimelate decarboxylase -
LBP97_RS12305 (LBP97_12325) 2601296..2602219 + 924 WP_025304080.1 LysR family transcriptional regulator -
LBP97_RS12310 (LBP97_12330) 2602247..2603155 - 909 WP_238968689.1 LysR family transcriptional regulator -
LBP97_RS12315 (LBP97_12335) 2603264..2604148 + 885 WP_049296175.1 MBL fold metallo-hydrolase -
LBP97_RS12320 (LBP97_12340) 2604217..2604864 + 648 WP_025304083.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13325.32 Da        Isoelectric Point: 10.6629

>T217256 WP_173888469.1 NZ_CP083754:2599220-2599564 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T217256 NZ_CP114128:c354548-354063 [Escherichia coli]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCTCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT217256 WP_025304078.1 NZ_CP083754:2599570-2599872 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT217256 NZ_CP114128:c354817-354539 [Escherichia coli]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCGTTGATGACGAGCAATACGATGCGTTTCTGGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCATTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References