Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 353317..353963 Replicon chromosome
Accession NZ_CP083751
Organism Klebsiella pneumoniae strain FAHZZU2591

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag LBE00_RS01640 Protein ID WP_016529833.1
Coordinates 353317..353664 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LBE00_RS01645 Protein ID WP_002920557.1
Coordinates 353664..353963 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBE00_RS01630 (LBE00_01630) 349243..350676 + 1434 WP_130974867.1 glycogen synthase GlgA -
LBE00_RS01635 (LBE00_01635) 350694..353141 + 2448 WP_021312822.1 glycogen phosphorylase -
LBE00_RS01640 (LBE00_01640) 353317..353664 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LBE00_RS01645 (LBE00_01645) 353664..353963 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LBE00_RS01650 (LBE00_01650) 354026..355534 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LBE00_RS01655 (LBE00_01655) 355739..356068 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LBE00_RS01660 (LBE00_01660) 356119..356949 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LBE00_RS01665 (LBE00_01665) 356999..357757 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T217224 WP_016529833.1 NZ_CP083751:353317-353664 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T217224 NZ_CP114058:c2197338-2197249 [Rouxiella chamberiensis]
GCCTGCATCAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAGTATAGGAATCGTACTCG
GTCTTTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT217224 WP_002920557.1 NZ_CP083751:353664-353963 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT217224 NZ_CP114058:2197249-2197338 [Rouxiella chamberiensis]
AAAAAAAGACCGAGTACGATTCCTATACTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TGATGCAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References