Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1743616..1744317 Replicon chromosome
Accession NZ_CP083746
Organism Pseudomonas sp. p1(2021b)

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag K8374_RS08040 Protein ID WP_224458584.1
Coordinates 1743616..1743912 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag K8374_RS08045 Protein ID WP_224458585.1
Coordinates 1743916..1744317 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8374_RS08020 (K8374_08020) 1739581..1740759 - 1179 WP_224458581.1 efflux RND transporter periplasmic adaptor subunit -
K8374_RS08025 (K8374_08025) 1740967..1741443 + 477 WP_084854853.1 sigma-70 family RNA polymerase sigma factor -
K8374_RS08030 (K8374_08030) 1741643..1742128 + 486 WP_224458582.1 histidine kinase -
K8374_RS08035 (K8374_08035) 1742196..1743521 + 1326 WP_224458583.1 MFS transporter -
K8374_RS08040 (K8374_08040) 1743616..1743912 + 297 WP_224458584.1 type II toxin-antitoxin system MqsR family toxin Toxin
K8374_RS08045 (K8374_08045) 1743916..1744317 + 402 WP_224458585.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
K8374_RS08050 (K8374_08050) 1744503..1746167 - 1665 WP_224458586.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
K8374_RS08055 (K8374_08055) 1746715..1747464 + 750 WP_196145707.1 electron transfer flavoprotein subunit beta/FixA family protein -
K8374_RS08060 (K8374_08060) 1747465..1748394 + 930 WP_084854765.1 FAD-binding protein -
K8374_RS08065 (K8374_08065) 1748472..1749293 + 822 WP_224458587.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11215.13 Da        Isoelectric Point: 9.5450

>T217215 WP_224458584.1 NZ_CP083746:1743616-1743912 [Pseudomonas sp. p1(2021b)]
MEKRTPHCPLERVRTLVAAGRVMPTASALRGALALGLDYQAMLEVIQSLERRDFFKSMTSFADHRIWQDVYRPRTGVGYV
YLKLSVIDDVLIVSFKEL

Download         Length: 297 bp

>T217215 NZ_CP114038:c3904448-3904098 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14647.79 Da        Isoelectric Point: 8.4902

>AT217215 WP_224458585.1 NZ_CP083746:1743916-1744317 [Pseudomonas sp. p1(2021b)]
MKCPICGGAKLVPGTQDMPYRYQGASTLIEKVRGDYCPACGEAVLSHGEAQRVSDVMSAFNRQVNAARVDPGFITAVRKK
FDLDQREAGEIFGGGVNAFSRYENGKTRPPVALVKLFKLLDRHPELFEEIRTA

Download         Length: 402 bp

>AT217215 NZ_CP114038:c3904735-3904454 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References