Detailed information of TA system TA217170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2681560..2681823
• Replicon: chromosome
• Accession: NZ_CP083728
• Organism: Staphylococcus aureus strain MR254

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: K9B11_RS13375
• Protein ID: WP_001802298.1
• Coordinates: 2681560..2681664 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2681659..2681823 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9B11_RS13345	2676944..2677726	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
K9B11_RS13350	2677794..2678651	+	858	WP_000370924.1	HAD family hydrolase	-
K9B11_RS13355	2678883..2679067	-	185	Protein_2596	exotoxin	-
K9B11_RS13360	2679356..2679448	-	93	WP_001790138.1	hypothetical protein	-
K9B11_RS13365	2679737..2680873	+	1137	WP_000115564.1	SAP domain-containing protein	-
K9B11_RS13370	2680916..2681399	+	484	Protein_2599	recombinase family protein	-
K9B11_RS13375	2681560..2681664	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2681659..2681823	-	165	-	-	Antitoxin
K9B11_RS13385	2682107..2683198	-	1092	WP_000495671.1	lytic regulatory protein	-
K9B11_RS13390	2683464..2684444	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
K9B11_RS13395	2684446..2684766	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
K9B11_RS13400	2684918..2685583	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-142)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T217170 WP_001802298.1 NZ_CP083728:2681560-2681664 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T217170 NZ_CP113942:753170-753676 [Bifidobacterium sp. ESL0682]
ATGATTGAAGAAAAACGAGTGGTTTTCGATACGAATGTGCTGCTGGACTATCTTCTCACCTGGCGTTCTGGTAACGCGAA
TGCTATACAACTTCTGCGTGCCTGTTCGAATTCGGAAATGATTAAGTTGCTTTGTGTCTCTCTATCTTTAAAAGATGTTG
ACTATATCTCGAGGTCATCGTTTAAAAAACAATTTGCAGGCAATGAATCTGTAGTTGTACAGGCTACCGTTTCCAATATG
GCTCCTAAGTTCGGTTGGCATTGCGTTGATGATTTATTGAAAATAATTGCATTGGTGGTTGCAGTCGATCAATCAACTTG
TAAGCATGCTCTCAAGTTATGGGATGTTCATCCTGATTATGAAGATGATCTCATTATTGCCGCGTCGCGTCAGGCCAACG
CCGACATGGTGGTGACGGGGGATCAGGATTTAATCAAGCATTTCCCGGATTTGTGCGTCAGTGTTGAGGACGCATTGAAG
CAGATTGACGGAACGGACCAAGGCTAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT217170 NZ_CP083728:c2681823-2681659 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin