Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2391335..2391519 Replicon chromosome
Accession NZ_CP083728
Organism Staphylococcus aureus strain MR254

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag K9B11_RS11855 Protein ID WP_000482650.1
Coordinates 2391335..2391442 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2391459..2391519 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9B11_RS11830 2386697..2387170 + 474 WP_000456489.1 GyrI-like domain-containing protein -
K9B11_RS11835 2387293..2388504 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
K9B11_RS11840 2388686..2389345 - 660 WP_000831298.1 membrane protein -
K9B11_RS11845 2389405..2390547 - 1143 WP_001176863.1 glycerate kinase -
K9B11_RS11850 2390815..2391201 + 387 WP_000779358.1 flippase GtxA -
K9B11_RS11855 2391335..2391442 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2391459..2391519 - 61 - - Antitoxin
K9B11_RS11860 2392070..2393833 + 1764 WP_001064838.1 ABC transporter ATP-binding protein -
K9B11_RS11865 2393858..2395591 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
K9B11_RS11870 2395822..2395989 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T217167 WP_000482650.1 NZ_CP083728:2391335-2391442 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T217167 NZ_CP113941:c1227926-1227735 [Lactobacillus sp. ESL0684]
ATGCCACTTACAGGAAAGGATATGTTAAAGTTGTTGCTAGATAATGGTTGGATTGAACGCAGAGTTGCTGGCTCACATCA
TCATTTATATAAAAATGGTGTAAGAATCACAATTCCTGTTCATGGAAATCAAGATTTAGGTAATGGACTTGAACGTAAAA
TCCTTAAAGAGGCTGGGCTAACCAGACATTAA

Antitoxin


Download         Length: 61 bp

>AT217167 NZ_CP083728:c2391519-2391459 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References