Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2359496..2360019 Replicon chromosome
Accession NZ_CP083728
Organism Staphylococcus aureus strain MR254

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag K9B11_RS11715 Protein ID WP_000074048.1
Coordinates 2359753..2360019 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag K9B11_RS11710 Protein ID WP_000587616.1
Coordinates 2359496..2359753 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9B11_RS11685 (2354576) 2354576..2355769 + 1194 WP_000675401.1 MFS transporter -
K9B11_RS11690 (2355993) 2355993..2356742 - 750 WP_224433942.1 CPBP family lipoprotein N-acylation protein LnsB -
K9B11_RS11695 (2356937) 2356937..2358514 + 1578 WP_031808290.1 FMN-binding glutamate synthase family protein -
K9B11_RS11700 (2358682) 2358682..2359137 - 456 WP_000732082.1 DUF1307 domain-containing protein -
K9B11_RS11705 (2359196) 2359196..2359390 + 195 WP_001790145.1 hypothetical protein -
K9B11_RS11710 (2359496) 2359496..2359753 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9B11_RS11715 (2359753) 2359753..2360019 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
K9B11_RS11720 (2360374) 2360374..2361450 + 1077 WP_224433943.1 M42 family metallopeptidase -
K9B11_RS11725 (2361698) 2361698..2362360 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
K9B11_RS11730 (2362353) 2362353..2363129 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
K9B11_RS11735 (2363525) 2363525..2364712 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T217166 WP_000074048.1 NZ_CP083728:2359753-2360019 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T217166 NZ_CP113939:1125314-1125604 [Bifidobacterium sp. ESL0690]
GTGGCACTGCAACAGATTGAACGCACTGCGACGTTTCTCCGACAAGCGAAGCAATTACGCCGTAAACACTACGATTTCGA
TAAGCTCGAGAAGGTCATTCGCCTCCTGATGGCGCAGGACCATGAGGTGTTGCGCCGCCGGTACCGTGACCACGCGTTGA
AAGGGAACCTGCGTAATTTTCGTGAGTTACACATCGAAGCGGATTGGCTGCTGATTTATCAGATCAAGGGTGACGTGTTG
ACGTTGGTGTTGGTGGAAACGGGTAGTCACCAGCAATTGCTCGGCAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT217166 WP_000587616.1 NZ_CP083728:2359496-2359753 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT217166 NZ_CP113939:1125073-1125333 [Bifidobacterium sp. ESL0690]
ATGAATAGCGCGACGATAGCGATTCGGACGGATCCACAGATCAAGAAGCAGGCCCAAGAGGTTTTCAAGGGGCTTGGATT
GGATATGAGCAGTGCCATCAATATGTTCTTGCAGCAGACCATCAATGACCGTGGTCTGCCTTTCCGTCCAACACTTTCCA
AGTTCGAGAAAGGGGTGTTGGACGCCGCCGAAGGCCCGACCCGCTCGTTCGACAATATCGACGATTTGATGAAGGAACTT
CGTGGCACTGCAACAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References