Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 24098..24362 | Replicon | plasmid p1606f |
| Accession | NZ_CP083707 | ||
| Organism | Escherichia coli strain SUISSEKPC3NDM5 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | K9O95_RS27565 | Protein ID | WP_001331364.1 |
| Coordinates | 24210..24362 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 24098..24160 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9O95_RS27550 (19337) | 19337..21628 | - | 2292 | WP_021520372.1 | F-type conjugative transfer protein TrbC | - |
| K9O95_RS27555 (21621) | 21621..22691 | - | 1071 | WP_001542508.1 | IncI1-type conjugal transfer protein TrbB | - |
| K9O95_RS27560 (22710) | 22710..23918 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (24098) | 24098..24160 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (24098) | 24098..24160 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (24098) | 24098..24160 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (24098) | 24098..24160 | - | 63 | NuclAT_0 | - | Antitoxin |
| K9O95_RS27565 (24210) | 24210..24362 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| K9O95_RS27570 (24434) | 24434..24685 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| K9O95_RS27575 (24985) | 24985..25281 | + | 297 | WP_001275298.1 | DinQ-like type I toxin DqlB | - |
| K9O95_RS27580 (25346) | 25346..25522 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| K9O95_RS27585 (25854) | 25854..26102 | + | 249 | WP_224451530.1 | HEAT repeat domain-containing protein | - |
| K9O95_RS27590 (26089) | 26089..27702 | - | 1614 | WP_000080195.1 | IS66-like element ISEc23 family transposase | - |
| K9O95_RS27595 (27733) | 27733..28083 | - | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| K9O95_RS27600 (28080) | 28080..28505 | - | 426 | WP_000422741.1 | transposase | - |
| K9O95_RS27605 (28675) | 28675..29337 | - | 663 | WP_000653333.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..107032 | 107032 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T217133 WP_001331364.1 NZ_CP083707:24210-24362 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T217133 NZ_CP113904:c5171364-5171077 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAATAAGTAATCTAAGAAAACATGGAATCCGGTTTGAGGAAGCGGT
GCTCGTCTTAGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAATAAGTAATCTAAGAAAACATGGAATCCGGTTTGAGGAAGCGGT
GCTCGTCTTAGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
Antitoxin
Download Length: 63 bp
>AT217133 NZ_CP083707:c24160-24098 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
