Detailed information of TA system TA217130

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 60575..60844
• Replicon: plasmid p1606d
• Accession: NZ_CP083705
• Organism: Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: K9O95_RS26400
• Protein ID: WP_001372321.1
• Coordinates: 60719..60844 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	60575..60640 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9O95_RS26365	56285..56812	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
K9O95_RS26370	56870..57103	+	234	WP_000006003.1	DUF905 family protein	-
K9O95_RS26375	57164..59187	+	2024	Protein_75	ParB/RepB/Spo0J family partition protein	-
K9O95_RS26380	59256..59690	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
K9O95_RS26385	59687..60449	+	763	Protein_77	plasmid SOS inhibition protein A	-
-	60418..60642	+	225	NuclAT_0	-	-
-	60418..60642	+	225	NuclAT_0	-	-
-	60418..60642	+	225	NuclAT_0	-	-
-	60418..60642	+	225	NuclAT_0	-	-
K9O95_RS26390	60427..60606	-	180	WP_001309233.1	hypothetical protein	-
-	60575..60640	-	66	-	-	Antitoxin
K9O95_RS26395	60628..60777	+	150	Protein_79	plasmid maintenance protein Mok	-
K9O95_RS26400	60719..60844	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
K9O95_RS26405	61163..61460	-	298	Protein_81	hypothetical protein	-
K9O95_RS26410	61760..62056	+	297	WP_001272251.1	hypothetical protein	-
K9O95_RS26415	62167..62988	+	822	WP_001234445.1	DUF932 domain-containing protein	-
K9O95_RS26420	63285..63875	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
K9O95_RS26425	64210..64593	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
K9O95_RS26430	64787..65458	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
K9O95_RS26435	65595..65822	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T217130 WP_001372321.1 NZ_CP083705:60719-60844 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T217130 NZ_CP113904:2114446-2114549 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 66 bp

>AT217130 NZ_CP083705:c60640-60575 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin