Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4416392..4417085 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K9O95_RS21610 Protein ID WP_000415584.1
Coordinates 4416392..4416688 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K9O95_RS21615 Protein ID WP_000650107.1
Coordinates 4416690..4417085 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS21575 (4411480) 4411480..4411794 - 315 WP_000958598.1 putative quinol monooxygenase -
K9O95_RS21580 (4411825) 4411825..4412406 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K9O95_RS21585 (4412725) 4412725..4413057 + 333 WP_000917684.1 DUF2645 family protein -
K9O95_RS21590 (4413103) 4413103..4414452 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K9O95_RS21595 (4414449) 4414449..4415108 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K9O95_RS21600 (4415260) 4415260..4415652 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K9O95_RS21605 (4415705) 4415705..4416187 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K9O95_RS21610 (4416392) 4416392..4416688 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K9O95_RS21615 (4416690) 4416690..4417085 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K9O95_RS21620 (4417218) 4417218..4418825 + 1608 WP_064221462.1 ABC transporter substrate-binding protein -
K9O95_RS21625 (4418963) 4418963..4421221 + 2259 WP_104763973.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T217114 WP_000415584.1 NZ_CP083701:4416392-4416688 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T217114 NZ_CP113832:2684835-2684939 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT217114 WP_000650107.1 NZ_CP083701:4416690-4417085 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT217114 NZ_CP113832:c2684695-2684541 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGTGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References