Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4303392..4304191 Replicon chromosome
Accession NZ_CP083701
Organism Escherichia coli strain SUISSEKPC3NDM5

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag K9O95_RS21060 Protein ID WP_000347251.1
Coordinates 4303392..4303856 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag K9O95_RS21065 Protein ID WP_001308975.1
Coordinates 4303856..4304191 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O95_RS21030 (4298393) 4298393..4298827 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
K9O95_RS21035 (4298845) 4298845..4299723 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
K9O95_RS21040 (4299713) 4299713..4300492 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
K9O95_RS21045 (4300503) 4300503..4300976 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
K9O95_RS21050 (4300999) 4300999..4302279 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
K9O95_RS21055 (4302528) 4302528..4303337 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
K9O95_RS21060 (4303392) 4303392..4303856 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
K9O95_RS21065 (4303856) 4303856..4304191 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
K9O95_RS21070 (4304340) 4304340..4305911 - 1572 WP_064221457.1 galactarate dehydratase -
K9O95_RS21075 (4306286) 4306286..4307620 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
K9O95_RS21080 (4307636) 4307636..4308406 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T217112 WP_000347251.1 NZ_CP083701:c4303856-4303392 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T217112 NZ_CP113832:c2612189-2612085 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
ACTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT217112 WP_001308975.1 NZ_CP083701:c4304191-4303856 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT217112 NZ_CP113832:2611966-2612152 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGTAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References