Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 543223..543725 | Replicon | chromosome |
| Accession | NZ_CP083701 | ||
| Organism | Escherichia coli strain SUISSEKPC3NDM5 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | K9O95_RS02585 | Protein ID | WP_000767829.1 |
| Coordinates | 543471..543725 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | K9O95_RS02580 | Protein ID | WP_001259255.1 |
| Coordinates | 543223..543474 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9O95_RS02555 (538400) | 538400..539467 | - | 1068 | WP_000080090.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| K9O95_RS02560 (539467) | 539467..540537 | - | 1071 | WP_224451481.1 | histidinol-phosphate transaminase | - |
| K9O95_RS02565 (540534) | 540534..541838 | - | 1305 | WP_001446927.1 | histidinol dehydrogenase | - |
| K9O95_RS02570 (541844) | 541844..542743 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| K9O95_RS02575 (542889) | 542889..542939 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| K9O95_RS02580 (543223) | 543223..543474 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| K9O95_RS02585 (543471) | 543471..543725 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| K9O95_RS02590 (543808) | 543808..544632 | + | 825 | WP_038989073.1 | SDR family oxidoreductase | - |
| K9O95_RS02595 (544678) | 544678..545607 | + | 930 | WP_064221651.1 | LysR substrate-binding domain-containing protein | - |
| K9O95_RS02600 (545822) | 545822..545884 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| K9O95_RS02605 (545874) | 545874..547232 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| K9O95_RS02610 (547412) | 547412..548470 | + | 1059 | WP_000492330.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| K9O95_RS02615 (548484) | 548484..548711 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T217093 WP_000767829.1 NZ_CP083701:543471-543725 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T217093 NZ_CP113827:c3845130-3844945 [Pandoraea sp. XJJ-1]
ATGAAGTACAGCGAATTCCGAAGGTGGCTTCGGCGAGAGGGCGCGACGTTCGAGCAGCACCGTGCCGGATCCAGTCACTT
TCGAGTCACGCTCAATGGGCGCTCGACGGTATTCCCGGATCATGGTGCCAAGGAGATGGGGCGCGGACTGGTGGAAGCCA
TCAAGAAACAGCTCGATCTGAAATAG
ATGAAGTACAGCGAATTCCGAAGGTGGCTTCGGCGAGAGGGCGCGACGTTCGAGCAGCACCGTGCCGGATCCAGTCACTT
TCGAGTCACGCTCAATGGGCGCTCGACGGTATTCCCGGATCATGGTGCCAAGGAGATGGGGCGCGGACTGGTGGAAGCCA
TCAAGAAACAGCTCGATCTGAAATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT217093 WP_001259255.1 NZ_CP083701:543223-543474 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT217093 NZ_CP113827:c3844901-3844482 [Pandoraea sp. XJJ-1]
ATGTTGACCTATCCCATTACGCTCAAGCGCGACACGAACGACACGTTGTTGGTCACGTTCCCGGATGTGCCGGAGGCGAT
TACCGTCGGCGAGAACGAGGCGCACGCGCGTGAGCAAGCGCTTGAAGCGCTTGAGGCGGCGCTGGAGTTTTACTTCGCAC
AGAAGCGGCCAATCCCGTGGCCGTCGCGTGCGAAGCGCGGGCAGGCCACGATCACGTTGCCAATCATGGCGTCGATCAAG
GTGCTGCTGGCGAACGAGATGATCGCGCAGAACGTGCGAAAGGCCGAGTTGGCCCGGCGTATGCACGTCAATCAGGTGCA
GGTGGATCGGTTATTGAAGCTCGGCTACGCCTCTCGCCTCGACGCGGTGGAGAACGCGTTTGCCGTGTTGGGCAAGCGGC
TGGAGGTGCGCGCGGTATAG
ATGTTGACCTATCCCATTACGCTCAAGCGCGACACGAACGACACGTTGTTGGTCACGTTCCCGGATGTGCCGGAGGCGAT
TACCGTCGGCGAGAACGAGGCGCACGCGCGTGAGCAAGCGCTTGAAGCGCTTGAGGCGGCGCTGGAGTTTTACTTCGCAC
AGAAGCGGCCAATCCCGTGGCCGTCGCGTGCGAAGCGCGGGCAGGCCACGATCACGTTGCCAATCATGGCGTCGATCAAG
GTGCTGCTGGCGAACGAGATGATCGCGCAGAACGTGCGAAAGGCCGAGTTGGCCCGGCGTATGCACGTCAATCAGGTGCA
GGTGGATCGGTTATTGAAGCTCGGCTACGCCTCTCGCCTCGACGCGGTGGAGAACGCGTTTGCCGTGTTGGGCAAGCGGC
TGGAGGTGCGCGCGGTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|