Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1101376..1102003 | Replicon | chromosome |
| Accession | NZ_CP083693 | ||
| Organism | Bartonella taylorii strain M1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LBE40_RS04910 | Protein ID | WP_004861506.1 |
| Coordinates | 1101689..1102003 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | LBE40_RS04905 | Protein ID | WP_004861504.1 |
| Coordinates | 1101376..1101672 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LBE40_RS04855 (LBE40_04865) | 1096873..1097124 | + | 252 | Protein_932 | single-stranded DNA-binding protein | - |
| LBE40_RS04860 (LBE40_04870) | 1097135..1097671 | + | 537 | WP_252615159.1 | hypothetical protein | - |
| LBE40_RS04865 (LBE40_04875) | 1097739..1097939 | + | 201 | WP_004861476.1 | type II toxin-antitoxin system HicA family toxin | - |
| LBE40_RS04870 (LBE40_04880) | 1097936..1098331 | + | 396 | WP_004861478.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LBE40_RS04875 (LBE40_04885) | 1098828..1099148 | + | 321 | WP_004861484.1 | hypothetical protein | - |
| LBE40_RS04880 (LBE40_04890) | 1099152..1099736 | + | 585 | WP_252615160.1 | hypothetical protein | - |
| LBE40_RS04885 (LBE40_04895) | 1100091..1100387 | + | 297 | WP_245256423.1 | hypothetical protein | - |
| LBE40_RS04890 (LBE40_04900) | 1100434..1100715 | - | 282 | WP_004861497.1 | type II toxin-antitoxin system YafQ family toxin | - |
| LBE40_RS04895 (LBE40_04905) | 1100702..1100965 | - | 264 | WP_004861501.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| LBE40_RS04900 (LBE40_04910) | 1101092..1101235 | - | 144 | WP_252615241.1 | hypothetical protein | - |
| LBE40_RS04905 (LBE40_04915) | 1101376..1101672 | - | 297 | WP_004861504.1 | HigA family addiction module antitoxin | Antitoxin |
| LBE40_RS04910 (LBE40_04920) | 1101689..1102003 | - | 315 | WP_004861506.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LBE40_RS04915 (LBE40_04925) | 1102066..1102647 | + | 582 | WP_004861509.1 | hypothetical protein | - |
| LBE40_RS04920 (LBE40_04930) | 1102640..1104568 | + | 1929 | WP_004858784.1 | phage terminase large subunit family protein | - |
| LBE40_RS04925 (LBE40_04935) | 1104572..1104820 | + | 249 | WP_004858786.1 | hypothetical protein | - |
| LBE40_RS04930 (LBE40_04940) | 1104820..1105467 | + | 648 | Protein_947 | phage portal protein | - |
| LBE40_RS04935 (LBE40_04945) | 1105753..1106742 | - | 990 | WP_252615236.1 | contractile injection system protein, VgrG/Pvc8 family | - |
| LBE40_RS04940 (LBE40_04950) | 1106742..1106996 | - | 255 | WP_155814738.1 | tail protein X | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1093587..1113728 | 20141 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12076.85 Da Isoelectric Point: 8.5010
>T217092 WP_004861506.1 NZ_CP083693:c1102003-1101689 [Bartonella taylorii]
MIHKRVNEGDLVIESFADKRCKDLLEGNSPKGFPTTLVRIAQRKLFMLDKAVDLKDLRSPPGNHLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH
MIHKRVNEGDLVIESFADKRCKDLLEGNSPKGFPTTLVRIAQRKLFMLDKAVDLKDLRSPPGNHLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH
Download Length: 315 bp
>T217092 NZ_CP113827:3657448-3657639 [Pandoraea sp. XJJ-1]
ATGACAAGCGCAGACATCATCAAACGACTGAAGGCCGCCGGGTTCACCGAAGTGTCGGTGCGAGGCAGCCACCACAAATT
TCGGCACGAGAACGGTCGAGTGGTGATCGTCCCGCACCCGAAAAAGGACATGCCGATTGGCACCGCCCGCTCGATCTTCA
AGCAAGCGGGCATTGACTGGAGAAGCGAATGA
ATGACAAGCGCAGACATCATCAAACGACTGAAGGCCGCCGGGTTCACCGAAGTGTCGGTGCGAGGCAGCCACCACAAATT
TCGGCACGAGAACGGTCGAGTGGTGATCGTCCCGCACCCGAAAAAGGACATGCCGATTGGCACCGCCCGCTCGATCTTCA
AGCAAGCGGGCATTGACTGGAGAAGCGAATGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11320.99 Da Isoelectric Point: 5.1546
>AT217092 WP_004861504.1 NZ_CP083693:c1101672-1101376 [Bartonella taylorii]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFAKINKFECRV
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFAKINKFECRV
Download Length: 297 bp
>AT217092 NZ_CP113827:3657636-3658031 [Pandoraea sp. XJJ-1]
ATGAAATATCCGATCTACGTGTGGCAAGAAGGCGATAGCGCCTTCGGCGCCGCGTTCCCGGATCTTCCGGGCGTGCACAC
CGCAGCCGATACGCTCGACGAACTCGAGCGCATGGCTCAGGAAGCCGTCGAGCTTATGTACGAAGACAGCGCCGAAGCGA
TCCCGGCCCCGACCTACGACATCCACAAGCTGCACGCGCACGAAGTGGATGACGGCTCGGGCTGCTGGATGTTCGTCGAC
ATCGATCTGTCGAAGGTCAGCAGCAAGGCGATTCGATTGAACATCAGCCTGCCCGAGCGTCTCGTACATCAAATCGACGC
TGTGGCCGAGAAGCGCCATATGTCGCGCTCGGCGTTCCTGGCGCTCGCGGCACAGCGCGAGATGGAACACGCATAA
ATGAAATATCCGATCTACGTGTGGCAAGAAGGCGATAGCGCCTTCGGCGCCGCGTTCCCGGATCTTCCGGGCGTGCACAC
CGCAGCCGATACGCTCGACGAACTCGAGCGCATGGCTCAGGAAGCCGTCGAGCTTATGTACGAAGACAGCGCCGAAGCGA
TCCCGGCCCCGACCTACGACATCCACAAGCTGCACGCGCACGAAGTGGATGACGGCTCGGGCTGCTGGATGTTCGTCGAC
ATCGATCTGTCGAAGGTCAGCAGCAAGGCGATTCGATTGAACATCAGCCTGCCCGAGCGTCTCGTACATCAAATCGACGC
TGTGGCCGAGAAGCGCCATATGTCGCGCTCGGCGTTCCTGGCGCTCGCGGCACAGCGCGAGATGGAACACGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|